Myoclonus and hypercalcemia in a dog with poorly differentiated lymphoproliferative neoplasia.
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Authors
Hare, Cassia HZ
Archer, Joy
Cloup, Emilie
Cardoso Alves, Lisa
Publication Date
2019-03-22Journal Title
Journal of Veterinary Internal Medicine
ISSN
0891-6640
Publisher
Wiley-Blackwell
Volume
33
Issue
2
Pages
856-861
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Hare, C. H., Archer, J., Cloup, E., Genain, M., Hughes, K., McCallum, K., & Cardoso Alves, L. (2019). Myoclonus and hypercalcemia in a dog with poorly differentiated lymphoproliferative neoplasia.. Journal of Veterinary Internal Medicine, 33 (2), 856-861. https://doi.org/10.1111/jvim.15398
Abstract
A 1-year, 8-month-old Rhodesian Ridgeback was presented with obtundation, ambulatory tetraparesis, and myoclonus. Initial clinical findings included ionized hypercalcemia with an apparent marked increase in parathyroid hormone, thrombocytopenia, and nonregenerative anemia. Low numbers of circulating atypical cells were noted on blood film evaluation. Brain magnetic resonance imaging identified an extra-axial contrast enhancing subtentorial lesion, and cerebrospinal fluid (CSF) analysis documented a marked atypical lymphocytic pleocytosis. Flow cytometry performed on the CSF demonstrated expression of only CD45, CD90, and MHC class II, with Pax5 positivity on subsequent immunohistochemistry. The final diagnosis was of B-cell lymphoblastic lymphoma or acute leukemia, given the distribution of disease and the presence of significant bone marrow infiltration alongside an aggressive clinical course. The unusual immunophenotype of the neoplastic cells and hypercalcemia presented antemortem diagnostic challenges, highlighting the need for a multidisciplinary approach and caution in the interpretation of clinical abnormalities in cases with multiple comorbidities.
Keywords
flow cytometry, immunohistochemistry, immunophenotyping, lymphoma, magnetic resonance imaging, seizures
Identifiers
External DOI: https://doi.org/10.1111/jvim.15398
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291489
Rights
Attribution-NonCommercial 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc/4.0/
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