Show simple item record

dc.contributor.authorMazarello Paes, Veenaen
dc.contributor.authorBarrett, Jessicaen
dc.contributor.authorTaylor-Robinson, David Cen
dc.contributor.authorChesters, Heatheren
dc.contributor.authorCharalampopoulos, Dimitriosen
dc.contributor.authorDunger, Daviden
dc.contributor.authorViner, Russell Men
dc.contributor.authorStephenson, Terence Jen
dc.date.accessioned2019-04-12T23:30:32Z
dc.date.available2019-04-12T23:30:32Z
dc.date.issued2019-08en
dc.identifier.issn1399-543X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291548
dc.description.abstractOBJECTIVE: A systematic review and meta-analysis was conducted to investigate if glycaemic control measured by glycated Haemoglobin (HbA1c) levels near diagnosis are predictive of future glycaemic outcomes and vascular complications in childhood onset type 1 diabetes (T1D). METHODS: Evidence was gathered using electronic databases (MEDLINE, EMBASE, Web of Science, CINAHL, Scopus and Cochrane Library up to February 2017) and snowballing techniques. Studies investigating the association between the exposure "early glycaemic control" and main outcome: "tracking of early control" and secondary outcome: risk of future complications; in children and young people aged 0 to 19 years at baseline; were systematically double-reviewed, quality assessed and outcome data extracted for synthesis and meta-analysis. FINDINGS: Five studies (N=4227 participants) were eligible. HbA1c levels were sub-optimal throughout the study period but tended to stabilise in a "track" by 6 months after T1D diagnosis. The group with low HbA1c <53mmol/mol (<7%) at baseline had lower long-term HbA1c levels than the higher HbA1c group. The estimated standardised mean difference between the sub groups showed a reduction of HbA1c levels on average by 1.6% (range -0.95 to -2.28%) from baseline. Only one study investigated the association between early glycaemic control and development of vascular complications in childhood onset T1D. INTERPRETATIONS: Glycaemic control after the first few months of childhood onset T1D, remains stable but sub-optimal for a decade. The low and high HbA1c levels at baseline seem to "track" in their respective tracks during the 10-year follow-up however, the initial difference between groups narrows over time. This article is protected by copyright. All rights reserved.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherBlackwell Publishing Inc.
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectHumansen
dc.subjectDiabetic Angiopathiesen
dc.subjectDiabetes Mellitus, Type 1en
dc.subjectHypoglycemic Agentsen
dc.subjectAdolescenten
dc.subjectChilden
dc.subjectGlycated Hemoglobin Aen
dc.titleEffect of early glycemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic review and meta-analysis.en
dc.typeArticle
prism.endingPage509
prism.issueIdentifier5en
prism.publicationDate2019en
prism.publicationNamePediatric diabetesen
prism.startingPage494
prism.volume20en
dc.identifier.doi10.17863/CAM.38706
dcterms.dateAccepted2019-03-25en
rioxxterms.versionofrecord10.1111/pedi.12850en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-08en
dc.contributor.orcidMazarello Paes, Veena [0000-0002-4283-6266]
dc.contributor.orcidBarrett, Jessica [0000-0003-1889-9803]
dc.contributor.orcidTaylor-Robinson, David C [0000-0002-5828-7724]
dc.contributor.orcidCharalampopoulos, Dimitrios [0000-0002-3763-3130]
dc.contributor.orcidDunger, David [0000-0002-2566-9304]
dc.identifier.eissn1399-5448
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)
pubs.funder-project-idBritish Heart Foundation (RG/18/13/33946)
cam.orpheus.successThu Jan 30 10:47:17 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-08-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record