Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis.
McClure, Mark E
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
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McClure, M. E., Wason, J., Gopaluni, S., Tieu, J., Smith, R., Jayne, D., & Jones, R. B. (2019). Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis.. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 25 (5), 217-223. https://doi.org/10.1097/rhu.0000000000001030
INTRODUCTION: The value of antineutrophil cytoplasmic antibody (ANCA) measurements among patients with an established diagnosis of ANCA-associated vasculitis (AAV) to assess disease activity or predict relapse remains controversial, but recent evidence suggests a possible role for rituximab-treated patients. PATIENTS AND METHODS: All patients with active vasculitis and positive proteinase 3 (PR3)-ANCA who were starting a 2-year treatment course of rituximab for induction of remission at Addenbrooke's Hospital between January 2011 and January 2016 were included in this study. Common department practice consists of 6 g of rituximab given over 2 years, concomitant corticosteroids (0.5-1.0 mg/kg) with rapid taper over 3 months, and cessation of oral maintenance immunosuppressive agents at time of first rituximab dose. Clinical and laboratory data were collected retrospectively using electronic patient records. RESULTS: Fifty-seven patients with current PR3-ANCA positivity were included in the analysis. Median follow-up was 59 months. PR3-ANCA negativity was achieved in 25 patients (44%) with a median time of 14 months. Clinical remission was achieved in 53 patients (93%) with a median time of 3 months. Among the 53 patients who achieved remission during follow-up, 24 (45%) relapsed with a median time to relapse of 36 months from remission. Both PR3-ANCA-negative status and 50% reduction in PR3-ANCA from baseline (as time-varying covariates) were significantly associated with a longer time to relapse (PR3-ANCA-negative status: hazards ratio, 0.08 [95% confidence interval, 0.01-0.63, p = 0.016]; 50% reduction in PR3-ANCA: hazards ratio, 0.25 [95% confidence interval, 0.18-0.99, p = 0.046]). CONCLUSIONS: Achieving and maintaining PR3-ANCA negativity after rituximab was associated with longer-lasting remission.
Humans, Antibodies, Antineutrophil Cytoplasmic, Immunologic Factors, Glucocorticoids, Enzyme-Linked Immunosorbent Assay, Remission Induction, Middle Aged, Female, Male, Myeloblastin, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Biomarkers, Rituximab
This work was not funded by any particular research grant. M.M. is a PhD student in receipt of an MRC-GSK Experimental Medicine Initiative to Explore New Therapies (EMINENT) fellowship.
External DOI: https://doi.org/10.1097/rhu.0000000000001030
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291575
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