Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration.
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Antonica, F., Orietti, L., Mort, R. L., & Zernicka-Goetz, M. (2019). Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration.. Developmental biology, 450 (2), 132-140. https://doi.org/10.1016/j.ydbio.2019.03.016
Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.
Blastocyst, Endoderm, Animals, Mice, Cell Cycle, Cell Movement, Embryonic Development
Wellcome Trust (098287/Z/12/Z)
ECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (669198)
External DOI: https://doi.org/10.1016/j.ydbio.2019.03.016
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291626
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/