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Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Antonica, Francesco 
Orietti, Lorenzo Carlo 
Mort, Richard Lester 
Zernicka-Goetz, Magdalena  ORCID logo  https://orcid.org/0000-0002-7004-2471

Abstract

Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.

Description

Keywords

4D live imaging, Mouse embryo, Post-implantation morphogenesis, Visceral endoderm, Animals, Blastocyst, Cell Cycle, Cell Movement, Embryonic Development, Endoderm, Mice

Journal Title

Dev Biol

Conference Name

Journal ISSN

0012-1606
1095-564X

Volume Title

450

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (098287/Z/12/Z)
European Research Council (669198)