Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor
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Authors
Zhao, Jiantao
Sauvage, Christopher
Bitton, Frédérique
Bauchet, Guillaume
Liu, Dan
Huang, Sanwen
Tieman, Denise M
Klee, Harry J
Causse, Mathilde
Journal Title
Nature Communications
ISSN
2041-1723
Publisher
Springer Nature
Volume
10
Issue
1
Number
1534
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Zhao, J., Sauvage, C., Zhao, J. H., Bitton, F., Bauchet, G., Liu, D., Huang, S., et al. (2019). Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor. Nature Communications, 10 (1. 1534)https://doi.org/10.1038/s41467-019-09462-w
Abstract
Tomato flavor has changed over the course of long-term domestication and intensive breeding. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies (GWAS) using 775 tomato accessions and 2,316,117 SNPs from three GWAS panels. We discover 305 significant associations for the contents of sugars, acids, amino acids, and flavor-related volatiles. We demonstrate that fruit citrate and malate contents have been impacted by selection during domestication and improvement, while sugar content has undergone less stringent selection. We suggest that it may be possible to significantly increase volatiles that positively contribute to consumer preferences while reducing unpleasant volatiles, by selection of the relevant allele combinations. Our results provide genetic insights into the influence of human selection on tomato flavor and demonstrate the benefits obtained from meta-analysis.
Sponsorship
J-T.Z. was funded by a Chinese Scholarship Council (CSC) scholarship.
Identifiers
External DOI: https://doi.org/10.1038/s41467-019-09462-w
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291645