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dc.contributor.authorZhao, Jiantaoen
dc.contributor.authorSauvage, Christopheren
dc.contributor.authorZhao, Jing Huaen
dc.contributor.authorBitton, Frédériqueen
dc.contributor.authorBauchet, Guillaumeen
dc.contributor.authorLiu, Danen
dc.contributor.authorHuang, Sanwenen
dc.contributor.authorTieman, Denise Men
dc.contributor.authorKlee, Harry Jen
dc.contributor.authorCausse, Mathildeen
dc.date.accessioned2019-04-15T23:30:52Z
dc.date.available2019-04-15T23:30:52Z
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291645
dc.description.abstractTomato flavor has changed over the course of long-term domestication and intensive breeding. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies (GWAS) using 775 tomato accessions and 2,316,117 SNPs from three GWAS panels. We discover 305 significant associations for the contents of sugars, acids, amino acids, and flavor-related volatiles. We demonstrate that fruit citrate and malate contents have been impacted by selection during domestication and improvement, while sugar content has undergone less stringent selection. We suggest that it may be possible to significantly increase volatiles that positively contribute to consumer preferences while reducing unpleasant volatiles, by selection of the relevant allele combinations. Our results provide genetic insights into the influence of human selection on tomato flavor and demonstrate the benefits obtained from meta-analysis.
dc.description.sponsorshipJ-T.Z. was funded by a Chinese Scholarship Council (CSC) scholarship.
dc.languageenen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMeta-analysis of genome-wide association studies provides insights into genetic control of tomato flavoren
dc.typeArticle
prism.issueIdentifier1en
prism.number1534en
prism.publicationNameNature Communicationsen
prism.volume10en
dc.identifier.doi10.17863/CAM.38803
dcterms.dateAccepted2019-03-04en
rioxxterms.versionofrecord10.1038/s41467-019-09462-wen
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-03-04en
dc.contributor.orcidZhao, Jing Hua [0000-0003-4930-3582]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-04-04en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International