Chopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases.
Gram, Anna M
Booty, Lee M
The EMBO journal
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Gram, A. M., Booty, L. M., & Bryant, C. (2019). Chopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases.. The EMBO journal, 38 (10)https://doi.org/10.15252/embj.2019102065
Inflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the ‘apoptotic’ caspase-8 can cleave Gasdermin D (GSDMD) leading to pyroptosis-like cell death and IL-1β release in murine macrophages [1-3]. Orning et al and Chen/Demarco et al also show that the NLRP3 inflammasome is activated downstream of active caspase-8, but they attribute this inflammasome activation to different pore-forming proteins, GSDMD and Pannexin-1, respectively [1, 3].
Caspases, Caspase 1, Apoptosis, Caspase 8, Inflammasomes, Pyroptosis, NLR Family, Pyrin Domain-Containing 3 Protein
WELLCOME TRUST (108045/Z/15/Z)
External DOI: https://doi.org/10.15252/embj.2019102065
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291674
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