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dc.contributor.authorGram, Anna Men
dc.contributor.authorBooty, Lee Men
dc.contributor.authorBryant, Clareen
dc.date.accessioned2019-04-15T23:31:34Z
dc.date.available2019-04-15T23:31:34Z
dc.date.issued2019-05en
dc.identifier.issn0261-4189
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291674
dc.description.abstractInflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the ‘apoptotic’ caspase-8 can cleave Gasdermin D (GSDMD) leading to pyroptosis-like cell death and IL-1β release in murine macrophages [1-3]. Orning et al and Chen/Demarco et al also show that the NLRP3 inflammasome is activated downstream of active caspase-8, but they attribute this inflammasome activation to different pore-forming proteins, GSDMD and Pannexin-1, respectively [1, 3].
dc.description.sponsorshipWellcome Trust
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectCaspasesen
dc.subjectCaspase 1en
dc.subjectApoptosisen
dc.subjectCaspase 8en
dc.subjectInflammasomesen
dc.subjectPyroptosisen
dc.subjectNLR Family, Pyrin Domain-Containing 3 Proteinen
dc.titleChopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases.en
dc.typeArticle
prism.issueIdentifier10en
prism.publicationDate2019en
prism.publicationNameThe EMBO journalen
prism.volume38en
dc.identifier.doi10.17863/CAM.38832
dcterms.dateAccepted2019-04-02en
rioxxterms.versionofrecord10.15252/embj.2019102065en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-05en
dc.contributor.orcidBryant, Clare [0000-0002-2924-0038]
dc.identifier.eissn1460-2075
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (108045/Z/15/Z)
cam.orpheus.successThu Jan 30 12:51:05 GMT 2020 - Embargo updated*
cam.orpheus.counter1*
rioxxterms.freetoread.startdate2019-11-30


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