Chopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases.
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Peer-reviewed
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Abstract
nflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the “apoptotic” caspase‐8 can cleave gasdermin D (GSDMD) leading to pyroptosis‐like cell death and IL‐1β release in murine macrophages (Orning et al, 2018; Sarhan et al, 2018; Chen et al, 2019). Orning et al and Chen/Demarco et al also show that the NLRP3 inflammasome is activated downstream of active caspase‐8, but they attribute this inflammasome activation to different pore‐forming proteins, GSDMD and pannexin‐1, respectively (Orning et al, 2018; Chen et al, 2019).
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Keywords
Apoptosis, Caspase 1, Caspase 8, Caspases, Inflammasomes, NLR Family, Pyrin Domain-Containing 3 Protein, Pyroptosis
Journal Title
EMBO J
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Journal ISSN
0261-4189
1460-2075
1460-2075
Volume Title
38
Publisher
Springer Science and Business Media LLC
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All rights reserved
Sponsorship
Wellcome Trust (108045/Z/15/Z)
Wellcome Trust