Nanocarriers targeting senescent cells
Translational Medicine of Aging
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Muñoz-Espín, D. (2019). Nanocarriers targeting senescent cells. Translational Medicine of Aging, 3 1-5. https://doi.org/10.1016/j.tma.2019.01.001
Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the pro- gression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative thera- peutic and diagnostic applications in translational medicine.
The laboratory of D.M.-E. is funded by Cancer Research UK (CRUK), the CRUK Cambridge Centre Early Detection Programme, the Medical Research Council (MRC), and the Royal Society.
External DOI: https://doi.org/10.1016/j.tma.2019.01.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291742
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/