Nanocarriers targeting senescent cells
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Muñoz-Espín, Daniel
Abstract
Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the pro- gression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative thera- peutic and diagnostic applications in translational medicine.
Description
Keywords
3206 Medical Biotechnology, 32 Biomedical and Clinical Sciences, Aging, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, 2 Aetiology, 5 Development of treatments and therapeutic interventions, Generic health relevance, 3 Good Health and Well Being
Journal Title
Translational Medicine of Aging
Conference Name
Journal ISSN
2468-5011
2468-5011
2468-5011
Volume Title
3
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Medical Research Council (MR/R000530/1)
The laboratory of D.M.-E. is funded by Cancer Research UK (CRUK), the CRUK Cambridge Centre Early Detection Programme, the Medical Research Council (MRC), and the Royal Society.