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dc.contributor.authorHan, Areumen
dc.contributor.authorKang, Hyo Jinen
dc.contributor.authorCho, Yooboken
dc.contributor.authorLee, Sunghoonen
dc.contributor.authorKim, Young Jooen
dc.contributor.authorGong, Sungen
dc.date.accessioned2019-04-16T23:32:09Z
dc.date.available2019-04-16T23:32:09Z
dc.date.issued2006-07-01en
dc.identifier.issn0305-1048
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291781
dc.description.abstractThe single nucleotide polymorphisms (SNPs) in conserved protein regions have been thought to be strong candidates that alter protein functions. Thus, we have developed SNP@Domain, a web resource, to identify SNPs within human protein domains. We annotated SNPs from dbSNP with protein structure-based as well as sequence-based domains: (i) structure-based using SCOP and (ii) sequence-based using Pfam to avoid conflicts from two domain assignment methodologies. Users can investigate SNPs within protein domains with 2D and 3D maps. We expect this visual annotation of SNPs within protein domains will help scientists select and interpret SNPs associated with diseases. A web interface for the SNP@Domain is freely available at http://snpnavigator.net/ and from http://bioportal.net/.
dc.description.sponsorshipThis project was supported by the Korean Ministry of Science and Technology (MOST) under grant number M10508040002-05N0804-00210 and M10407010001-05N0701-00100. Y.B.C. is supported by Biogreen21 program (20050401-034-791-006-03-00 and 20050301-034-481-006-02-00). Funding to pay the Open Access publication charges for this article was provided by M10407010001-05N0701-00100 grant of MOST.
dc.languageengen
dc.publisherOxford University Press
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectComputer Graphicsen
dc.subjectDatabases, Proteinen
dc.subjectHumansen
dc.subjectInterneten
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectProtein Structure, Tertiaryen
dc.subjectSequence Analysis, Proteinen
dc.subjectSoftwareen
dc.subjectUser-Computer Interfaceen
dc.titleSNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences.en
dc.typeArticle
prism.endingPageW644
prism.issueIdentifierWeb Server issueen
prism.publicationDate2006en
prism.publicationNameNucleic Acids Researchen
prism.startingPageW642
prism.volume34en
dc.identifier.doi10.17863/CAM.38941
dcterms.dateAccepted2006-04-13en
rioxxterms.versionofrecord10.1093/nar/gkl323en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/en
rioxxterms.licenseref.startdate2006-07-01en
dc.contributor.orcidGong, Sung [0000-0001-5796-4423]
dc.identifier.eissn1362-4962
rioxxterms.typeJournal Article/Reviewen


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International