Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.
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Authors
Crawford, Robin
Latimer, John
Baldwin, Peter
Parkinson, Christine A
Smith, Sarah A
Moore, Elizabeth
Jimenez-Linan, Mercedes
Brodie, Cara
Addley, Helen C
Freeman, Susan J
Moyle, Penelope L
Publication Date
2019-01Journal Title
European journal of radiology open
ISSN
2352-0477
Publisher
Elsevier
Volume
6
Pages
156-162
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic-eCollection
Metadata
Show full item recordCitation
Deen, S., Riemer, F., McLean, M., Gill, A., Kaggie, J., Grist, J., Crawford, R., et al. (2019). Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.. European journal of radiology open, 6 156-162. https://doi.org/10.1016/j.ejro.2019.04.001
Abstract
The aim of this study was to assess the feasibility of rapid
sodium MRI (23Na-MRI) for the imaging of peritoneal cancer deposits in
high grade serous ovarian cancer (HGSOC) and to evaluate the relationship
of 23Na-MRI with tumour cellularity. 23Na-MRI was performed at 3T on
twelve HGSOC patients using a 3D-cones acquisition technique. Tumour
biopsies specimens were collected after imaging and cellularity was
measured from histology. Total 23Na-MRI scan time for each patient was
approximately 11 minutes. At an isotropic resolution of 5.6 mm, signalto-
noise ratios (SNRs) of 82.2 ± 15.3 and 15.1 ± 7.1 (mean ± standard
deviation) were achieved for imaging of tumour tissue sodium
concentration (TSC) and intracellular weighted sodium concentration (IWS)
respectively. Tumour TSC and IWS concentrations were: 56.8 ± 19.1 mM and
30.8 ± 9.2 mM respectively and skeletal muscle TSC and IWS concentrations
were 33.2 ± 16.3 mM and 20.5 ± 9.9 mM respectively. There were
significant sodium concentration differences between cancer and skeletal
muscle, Wilcoxon signed-rank test, P < 0.001 for TSC and P = 0.01 for IWS
imaging. Tumour cellularity displayed a strong negative correlation with
TSC, Spearman's rho = -0.92, P < 0.001, but did not correlate with IWS.
This study demonstrates that 23Na-MRI using 3D-cones can rapidly assess
sodium concentration in peritoneal deposits of HGSOC and that TSC may
serve as a biomarker of tumour cellularity.
Sponsorship
CRUK
Funder references
Cancer Research UK (16465)
MRC (1508766)
Identifiers
External DOI: https://doi.org/10.1016/j.ejro.2019.04.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/292019
Rights
All rights reserved, Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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