APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 Phase in Multicellular Systems
Trends in Cell Biology
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Kimata, Y. (2019). APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 Phase in Multicellular Systems. Trends in Cell Biology https://doi.org/10.1016/j.tcb.2019.03.001
The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology of multicellular organisms is far from complete. Here, I review recent advances in the function of APC/C in animal development, specifically focusing on its emerging role in regulating cell differentiation. I describe how APC/C regulates distinct processes during the course of differentiation by deploying diverse molecular machineries in a variety of developmental contexts. Also, I discuss the significance and clinical relevance of the unique capacity of APC/C and other cell cycle regulators to couple distinct cellular processes with cell proliferation control.
APC/C, development, differentiation, cell cycle, G1/G0, ubiquitination
This work is supported by the start-up funding from ShanghaiTech University (2018F0202-000-06) and Cancer Research UK (CRUK-A12874) to Y.K.
External DOI: https://doi.org/10.1016/j.tcb.2019.03.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/292095
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Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/