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dc.contributor.authorKimata, Yuu
dc.date.accessioned2019-04-29T23:30:45Z
dc.date.available2019-04-29T23:30:45Z
dc.date.issued2019-07
dc.identifier.issn0962-8924
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292095
dc.description.abstractThe anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology of multicellular organisms is far from complete. Here, I review recent advances in the function of APC/C in animal development, specifically focusing on its emerging role in regulating cell differentiation. I describe how APC/C regulates distinct processes during the course of differentiation by deploying diverse molecular machineries in a variety of developmental contexts. Also, I discuss the significance and clinical relevance of the unique capacity of APC/C and other cell cycle regulators to couple distinct cellular processes with cell proliferation control.
dc.description.sponsorshipThis work is supported by the start-up funding from ShanghaiTech University (2018F0202-000-06) and Cancer Research UK (CRUK-A12874) to Y.K.
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAPC/C
dc.subjectdevelopment
dc.subjectdifferentiation
dc.subjectcell cycle
dc.subjectG1/G0
dc.subjectubiquitination
dc.titleAPC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 Phase in Multicellular Systems
dc.typeArticle
prism.publicationNameTrends in Cell Biology
dc.identifier.doi10.17863/CAM.39250
dcterms.dateAccepted2019-03-01
rioxxterms.versionofrecord10.1016/j.tcb.2019.03.001
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-03-01
dc.contributor.orcidKimata, Yuu [0000-0001-6223-1320]
dc.identifier.eissn1879-3088
rioxxterms.typeJournal Article/Review
cam.issuedOnline2019-04-15
cam.orpheus.successThu Jan 30 10:45:59 GMT 2020 - Embargo updated
rioxxterms.freetoread.startdate2020-04-15


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International