Looking back on the alternative complement pathway.
Lachmann, Peter J
The alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge. This paper reviews this history and attempts to clarify some of the ambiguities that remain.
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Alternative pathway, Complement, Properdin, Animals, Complement Pathway, Alternative, History, 20th Century, History, 21st Century, Humans, Properdin