Looking back on the alternative complement pathway.

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dc.contributor.authorLachmann, Peter J
dc.date.accessioned2019-04-30T13:58:42Z
dc.date.available2019-04-30T13:58:42Z
dc.date.issued2018-08
dc.identifier.issn0171-2985
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292129
dc.description.abstractThe alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge. This paper reviews this history and attempts to clarify some of the ambiguities that remain.
dc.languageeng
dc.publisherElsevier
dc.subjectAlternative pathway
dc.subjectComplement
dc.subjectProperdin
dc.subjectAnimals
dc.subjectComplement Pathway, Alternative
dc.subjectHistory, 20th Century
dc.subjectHistory, 21st Century
dc.subjectHumans
dc.subjectProperdin
dc.titleLooking back on the alternative complement pathway.
dc.typeArticle
prism.endingPage523
prism.issueIdentifier8-9
prism.publicationDate2018
prism.publicationNameImmunobiology
prism.startingPage519
prism.volume223
dc.identifier.doi10.17863/CAM.39281
dcterms.dateAccepted2018-02-27
rioxxterms.versionofrecord10.1016/j.imbio.2018.02.001
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidLachmann, Sir Peter [0000-0003-2849-3524]
dc.identifier.eissn1878-3279
dc.publisher.urlhttps://www.sciencedirect.com/science/article/pii/S0171298518300184?via%3Dihub#ack0005
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-03-06
rioxxterms.freetoread.startdate2019-03-06


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