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Multiscale dynamics of branching morphogenesis.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Hannezo, Edouard 
Simons, Benjamin D 

Abstract

Branching morphogenesis is a prototypical example of complex three-dimensional organ sculpting, required in multiple developmental settings to maximize the area of exchange surfaces. It requires, in particular, the coordinated growth of different cell types together with complex patterning to lead to robust macroscopic outputs. In recent years, novel multiscale quantitative biology approaches, together with biophysical modelling, have begun to shed new light of this topic. Here, we wish to review some of these recent developments, highlighting the generic design principles that can be abstracted across different branched organs, as well as the implications for the broader fields of stem cell, developmental and systems biology.

Description

Keywords

Animals, Models, Biological, Morphogenesis, Stem Cells

Journal Title

Curr Opin Cell Biol

Conference Name

Journal ISSN

0955-0674
1879-0410

Volume Title

60

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (098357/Z/12/Z)
Royal Society (RP/R1/180165)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (110326/Z/15/Z)
Cancer Research Uk (None)
Medical Research Council (MC_PC_12009)
wellcome trust royal society