Multiscale dynamics of branching morphogenesis.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Hannezo, Edouard
Simons, Benjamin D
Abstract
Branching morphogenesis is a prototypical example of complex three-dimensional organ sculpting, required in multiple developmental settings to maximize the area of exchange surfaces. It requires, in particular, the coordinated growth of different cell types together with complex patterning to lead to robust macroscopic outputs. In recent years, novel multiscale quantitative biology approaches, together with biophysical modelling, have begun to shed new light of this topic. Here, we wish to review some of these recent developments, highlighting the generic design principles that can be abstracted across different branched organs, as well as the implications for the broader fields of stem cell, developmental and systems biology.
Description
Keywords
Animals, Models, Biological, Morphogenesis, Stem Cells
Journal Title
Curr Opin Cell Biol
Conference Name
Journal ISSN
0955-0674
1879-0410
1879-0410
Volume Title
60
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Wellcome Trust (098357/Z/12/Z)
Royal Society (RP/R1/180165)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (110326/Z/15/Z)
Cancer Research Uk (None)
Medical Research Council (MC_PC_12009)
Royal Society (RP/R1/180165)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (110326/Z/15/Z)
Cancer Research Uk (None)
Medical Research Council (MC_PC_12009)
wellcome trust
royal society