Multiscale dynamics of branching morphogenesis.
Current opinion in cell biology
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Hannezo, E., & Simons, B. (2019). Multiscale dynamics of branching morphogenesis.. Current opinion in cell biology, 60 99-105. https://doi.org/10.1016/j.ceb.2019.04.008
Branching morphogenesis is a prototypical example of complex three-dimensional organ sculpting, required in multiple developmental settings to maximize the area of exchange surfaces. It requires, in particular, the coordinated growth of different cell types together with complex patterning to lead to robust macroscopic outputs. In recent years, novel multiscale quantitative biology approaches, together with biophysical modelling, have begun to shed new light of this topic. Here, we wish review some of these recent developments, highlighting the generic design principles that can be abstracted across different branched organs, as well as the implications for the broader fields of stem cell, developmental and systems biology.
Stem Cells, Animals, Morphogenesis, Models, Biological
wellcome trust royal society
Wellcome Trust (092096/Z/10/Z)
WELLCOME TRUST (110326/Z/15/Z)
Cancer Research UK (A14492)
Royal Society (RP/R1/180165)
Wellcome Trust (098357/Z/12/Z)
External DOI: https://doi.org/10.1016/j.ceb.2019.04.008
This record's URL: https://www.repository.cam.ac.uk/handle/1810/292239
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/