Show simple item record

dc.contributor.authorPyrillou, Katerina
dc.contributor.authorChairakaki, Aikaterini-Dimitra
dc.contributor.authorTamvakopoulos, Constantin
dc.contributor.authorAndreakos, Evangelos
dc.date.accessioned2019-05-03T09:10:39Z
dc.date.available2019-05-03T09:10:39Z
dc.date.issued2018-08
dc.identifier.issn1097-6825
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292291
dc.description.abstractTo the Editor: Resolution of inflammation has long been considered to be a passive process that ensues in an inflammatory response following the dilution of proinflammatory cues. However, this paradigm is shifting as it is becoming increasingly evident that resolution is an active reaction that uses a complex molecular machinery that orderly terminates inflammation. Among the multiple mechanisms involved, specialized proresolving lipid mediators (SPMs) such as resolvins, protectins, and lipoxins have taken center stage.1 These are derived from ω3 and ω6 polyunsaturated fatty acids through complex intracellular and transcellular biosynthetic pathways, and promote resolution of inflammation by their manifold and concerted functions inhibiting leukocyte trafficking, dampening proinflammatory signaling, inducing apoptosis, and promoting anti-inflammatory M2-like macrophage phenotypes, efferocytosis, and tissue restitution.1
dc.description.sponsorshipThis work was supported by core funding from the Hellenic Ministry of Education, Research and Religious Affairs and the Hellenic Ministry of Health, and by the research grants PREDICTA (contract no. 260895) from the European Commission, MIDAS (contract no. MIS 377047), and RESOLVE-ASTHMA (contract no. 2601) from the Hellenic Ministry of Education, Research and Religious Affairs.
dc.languageeng
dc.publisherMosby Inc.
dc.titleDexamethasone induces ω3-derived immunoresolvents driving resolution of allergic airway inflammation.
dc.typeArticle
prism.endingPage695.e4
prism.issueIdentifier2
prism.publicationDate2018
prism.publicationNameJournal of Allergy and Clinical Immunology
prism.startingPage691
prism.volume142
dc.identifier.doi10.17863/CAM.39440
dcterms.dateAccepted2018-04-06
rioxxterms.versionofrecord10.1016/j.jaci.2018.04.004
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidPyrillou, Katerina [0000-0003-0375-7810]
dc.identifier.eissn1097-6825
dc.publisher.urlhttps://www.sciencedirect.com/science/article/pii/S0091674918306122?via%3Dihub#!
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-04-24
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0091674918306122?via%3Dihub#!


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record