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dc.contributor.authorPetrillo, Antonella
dc.contributor.authorFusco, Roberta
dc.contributor.authorPetrillo, Mario
dc.contributor.authorGranata, Vincenza
dc.contributor.authorDelrio, Paolo
dc.contributor.authorBianco, Francesco
dc.contributor.authorPecori, Biagio
dc.contributor.authorBotti, Gerardo
dc.contributor.authorTatangelo, Fabiana
dc.contributor.authorCaracò, Corradina
dc.contributor.authorAloj, Luigi
dc.contributor.authorAvallone, Antonio
dc.contributor.authorLastoria, Secondo
dc.date.accessioned2019-05-03T18:35:33Z
dc.date.available2019-05-03T18:35:33Z
dc.date.issued2017-01-31
dc.identifier.issn1949-2553
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292312
dc.description.abstractPURPOSE: To investigate dynamic contrast enhanced-MRI (DCE-MRI) in the preoperative chemo-radiotherapy (CRT) assessment for locally advanced rectal cancer (LARC) compared to18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). METHODS: 75 consecutive patients with LARC were enrolled in a prospective study. DCE-MRI analysis was performed measuring SIS: linear combination of percentage change (Δ) of maximum signal difference (MSD) and wash-out slope (WOS). 18F-FDG PET/CT analysis was performed using SUV maximum (SUVmax). Tumor regression grade (TRG) were estimated after surgery. Non-parametric tests, receiver operating characteristic were evaluated. RESULTS: 55 patients (TRG1-2) were classified as responders while 20 subjects as non responders. ΔSIS reached sensitivity of 93%, specificity of 80% and accuracy of 89% (cut-off 6%) to differentiate responders by non responders, sensitivity of 93%, specificity of 69% and accuracy of 79% (cut-off 30%) to identify pathological complete response (pCR). Therapy assessment via ΔSUVmax reached sensitivity of 67%, specificity of 75% and accuracy of 70% (cut-off 60%) to differentiate responders by non responders and sensitivity of 80%, specificity of 31% and accuracy of 51% (cut-off 44%) to identify pCR. CONCLUSIONS: CRT response assessment by DCE-MRI analysis shows a higher predictive ability than 18F-FDG PET/CT in LARC patients allowing to better discriminate significant and pCR.
dc.format.mediumPrint
dc.languageeng
dc.publisherImpact Journals, LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectRectal Neoplasms
dc.subjectSiloxanes
dc.subjectFluorodeoxyglucose F18
dc.subjectContrast Media
dc.subjectRadiopharmaceuticals
dc.subjectMagnetic Resonance Imaging
dc.subjectTreatment Outcome
dc.subjectNeoadjuvant Therapy
dc.subjectRemission Induction
dc.subjectDigestive System Surgical Procedures
dc.subjectArea Under Curve
dc.subjectReproducibility of Results
dc.subjectPredictive Value of Tests
dc.subjectROC Curve
dc.subjectRegional Blood Flow
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectPerfusion Imaging
dc.subjectMagnetite Nanoparticles
dc.subjectChemoradiotherapy, Adjuvant
dc.subjectPositron Emission Tomography Computed Tomography
dc.titleStandardized Index of Shape (DCE-MRI) and Standardized Uptake Value (PET/CT): Two quantitative approaches to discriminate chemo-radiotherapy locally advanced rectal cancer responders under a functional profile.
dc.typeArticle
prism.endingPage8153
prism.issueIdentifier5
prism.publicationDate2017
prism.publicationNameOncotarget
prism.startingPage8143
prism.volume8
dc.identifier.doi10.17863/CAM.39463
dcterms.dateAccepted2016-11-21
rioxxterms.versionofrecord10.18632/oncotarget.14106
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-01
dc.contributor.orcidAloj, Luigi [0000-0002-7452-4961]
dc.identifier.eissn1949-2553
rioxxterms.typeJournal Article/Review
cam.issuedOnline2016-12-22


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International