Challenges to curing primary brain tumours.
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Authors
Aldape, Kenneth
Chesler, Louis
Chopra, Rajesh
Gajjar, Amar
Gilbert, Mark R
Gottardo, Nicholas
Gutmann, David H
Hargrave, Darren
Holland, Eric C
Jones, David TW
Joyce, Johanna A
Kearns, Pamela
Kieran, Mark W
Mellinghoff, Ingo K
Merchant, Melinda
Pfister, Stefan M
Pollard, Steven M
Rich, Jeremy N
Sampson, John H
Taylor, Michael D
Workman, Paul
Publication Date
2019-08Journal Title
Nat Rev Clin Oncol
ISSN
1759-4774
Publisher
Springer Science and Business Media LLC
Volume
16
Issue
8
Pages
509-520
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print
Metadata
Show full item recordCitation
Aldape, K., Brindle, K., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., et al. (2019). Challenges to curing primary brain tumours.. Nat Rev Clin Oncol, 16 (8), 509-520. https://doi.org/10.1038/s41571-019-0177-5
Abstract
Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.
Keywords
Humans, Brain Neoplasms
Sponsorship
National Cancer Institute (P01CA096832)
Medical Research Council (MC_PC_12009)
Identifiers
External DOI: https://doi.org/10.1038/s41571-019-0177-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/292483
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