The habenula encodes negative motivational value associated with primary punishment in humans.
View / Open Files
Lawson, Rebecca P
Dolan, Raymond J
Roiser, Jonathan P
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences
MetadataShow full item record
Lawson, R. P., Seymour, B., Loh, E., Lutti, A., Dolan, R. J., Dayan, P., Weiskopf, N., & et al. (2014). The habenula encodes negative motivational value associated with primary punishment in humans.. Proc Natl Acad Sci U S A, 111 (32), 11858-11863. https://doi.org/10.1073/pnas.1323586111
Learning what to approach, and what to avoid, involves assigning value to environmental cues that predict positive and negative events. Studies in animals indicate that the lateral habenula encodes the previously learned negative motivational value of stimuli. However, involvement of the habenula in dynamic trial-by-trial aversive learning has not been assessed, and the functional role of this structure in humans remains poorly characterized, in part, due to its small size. Using high-resolution functional neuroimaging and computational modeling of reinforcement learning, we demonstrate positive habenula responses to the dynamically changing values of cues signaling painful electric shocks, which predict behavioral suppression of responses to those cues across individuals. By contrast, negative habenula responses to monetary reward cue values predict behavioral invigoration. Our findings show that the habenula plays a key role in an online aversive learning system and in generating associated motivated behavior in humans.
conditioned behavior, high-resolution fMRI, pallidum, Adult, Animals, Conditioning, Psychological, Cues, Female, Functional Neuroimaging, Habenula, Humans, Learning, Magnetic Resonance Imaging, Male, Motivation, Punishment, Reinforcement, Psychology, Species Specificity, Young Adult
External DOI: https://doi.org/10.1073/pnas.1323586111
This record's URL: https://www.repository.cam.ac.uk/handle/1810/292537
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: email@example.com