Show simple item record

dc.contributor.authorLawson, Rebecca
dc.contributor.authorSeymour, Benjamin
dc.contributor.authorLoh, Eleanor
dc.contributor.authorLutti, Antoine
dc.contributor.authorDolan, Raymond J
dc.contributor.authorDayan, Peter
dc.contributor.authorWeiskopf, Nikolaus
dc.contributor.authorRoiser, Jonathan P
dc.date.accessioned2019-05-08T14:08:51Z
dc.date.available2019-05-08T14:08:51Z
dc.date.issued2014-08-12
dc.identifier.issn0027-8424
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292537
dc.description.abstractLearning what to approach, and what to avoid, involves assigning value to environmental cues that predict positive and negative events. Studies in animals indicate that the lateral habenula encodes the previously learned negative motivational value of stimuli. However, involvement of the habenula in dynamic trial-by-trial aversive learning has not been assessed, and the functional role of this structure in humans remains poorly characterized, in part, due to its small size. Using high-resolution functional neuroimaging and computational modeling of reinforcement learning, we demonstrate positive habenula responses to the dynamically changing values of cues signaling painful electric shocks, which predict behavioral suppression of responses to those cues across individuals. By contrast, negative habenula responses to monetary reward cue values predict behavioral invigoration. Our findings show that the habenula plays a key role in an online aversive learning system and in generating associated motivated behavior in humans.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherProceedings of the National Academy of Sciences
dc.subjectHabenula
dc.subjectAnimals
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMotivation
dc.subjectLearning
dc.subjectCues
dc.subjectPunishment
dc.subjectSpecies Specificity
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectFunctional Neuroimaging
dc.subjectConditioning, Psychological
dc.subjectReinforcement, Psychology
dc.titleThe habenula encodes negative motivational value associated with primary punishment in humans.
dc.typeArticle
prism.endingPage11863
prism.issueIdentifier32
prism.publicationDate2014
prism.publicationNameProc Natl Acad Sci U S A
prism.startingPage11858
prism.volume111
dc.identifier.doi10.17863/CAM.39696
rioxxterms.versionofrecord10.1073/pnas.1323586111
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2014-08
dc.contributor.orcidLawson, Rebecca [0000-0003-1228-1244]
dc.contributor.orcidSeymour, Benjamin [0000-0003-1724-5832]
dc.identifier.eissn1091-6490
rioxxterms.typeJournal Article/Review
cam.issuedOnline2014-07-28


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record