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dc.contributor.authorSchrezenmeier, Evaen
dc.contributor.authorJayne, Daviden
dc.contributor.authorDörner, Thomasen
dc.date.accessioned2019-05-13T23:30:21Z
dc.date.available2019-05-13T23:30:21Z
dc.date.issued2018-03en
dc.identifier.issn1046-6673
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292727
dc.description.abstractThe unique contributions of memory B cells and plasma cells in kidney diseases remain unclear. In this review, we evaluate the clinical experience with treatments directed at B cells, such as rituximab, and at plasma cells, such as proteasome inhibition, to shed light on the role of these two B lineage compartments in glomerular diseases. Specifically, analysis of these targeted interventions in diseases such as ANCA-associated vasculitis, SLE, and antibody-mediated transplant rejection permits insight into the pathogenetic effect of these cells. Notwithstanding the limitations of preclinical models and clinical studies (heterogeneous populations, among others), the data suggest that memory B and plasma cells represent two engines of autoimmunity, with variable involvement in these diseases. Whereas memory B cells and plasma cells appear to be key in ANCA-associated vasculitis and antibody-mediated transplant rejection, respectively, SLE seems likely to be driven by both autoimmune compartments. These conclusions have implications for the future development of targeted therapeutics in immune-mediated renal disease.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectB-Lymphocytesen
dc.subjectPlasma Cellsen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectLupus Nephritisen
dc.subjectAntibodies, Monoclonalen
dc.subjectKidney Transplantationen
dc.subjectAutoimmunityen
dc.subjectGraft Rejectionen
dc.subjectImmunologic Memoryen
dc.subjectCell Lineageen
dc.subjectAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitisen
dc.subjectMolecular Targeted Therapyen
dc.titleTargeting B Cells and Plasma Cells in Glomerular Diseases: Translational Perspectives.en
dc.typeArticle
prism.endingPage758
prism.issueIdentifier3en
prism.publicationDate2018en
prism.publicationNameJournal of the American Society of Nephrology : JASNen
prism.startingPage741
prism.volume29en
dc.identifier.doi10.17863/CAM.39884
dcterms.dateAccepted2018-01-25en
rioxxterms.versionofrecord10.1681/asn.2017040367en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-03en
dc.contributor.orcidJayne, David [0000-0002-1712-0637]
dc.identifier.eissn1533-3450
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2019-03-31


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