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dc.contributor.authorWalter, Fionaen
dc.contributor.authorThompson, Matthew Jen
dc.contributor.authorWellwood, Ianen
dc.contributor.authorAbel, Gary Aen
dc.contributor.authorHamilton, Williamen
dc.contributor.authorJohnson, Margareten
dc.contributor.authorLyratzopoulos, Georgiosen
dc.contributor.authorMessenger, Michael Pen
dc.contributor.authorNeal, Richard Den
dc.contributor.authorRubin, Gregen
dc.contributor.authorSingh, Hardeepen
dc.contributor.authorSpencer, Anneen
dc.contributor.authorSutton, Stephenen
dc.contributor.authorVedsted, Peteren
dc.contributor.authorEmery, Jon Den
dc.date.accessioned2019-05-22T23:30:29Z
dc.date.available2019-05-22T23:30:29Z
dc.date.issued2019-06-14en
dc.identifier.issn1471-2407
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293063
dc.description.abstractBackground Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, while minimising over-investigation and over-diagnosis. Methods We performed a systematic scoping review of frameworks for the evaluation of tests and diagnostic approaches. Results We identified 16 frameworks: none addressed the entire continuum from test development to impact on diagnosis and patient outcomes in the intended population, nor the way in which tests may be used for triage purposes as part of a wider diagnostic strategy. Informed by these findings, we developed a new framework, the ‘CanTest Framework’, which proposes five iterative research phases forming a clear translational pathway from new test development to health system implementation and evaluation. Conclusion This framework is suitable for testing in low prevalence populations, where tests are often applied for triage testing and incorporated into a wider diagnostic strategy. It has relevance for a wide range of stakeholders including patients, policymakers, purchasers, healthcare providers and industry.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherBioMed Central
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectHumansen
dc.subjectNeoplasmsen
dc.subjectModels, Biologicalen
dc.subjectTriageen
dc.subjectEarly Detection of Canceren
dc.titleEvaluating diagnostic strategies for early detection of cancer: the CanTest framework.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2019en
prism.publicationNameBMC canceren
prism.startingPage586
prism.volume19en
dc.identifier.doi10.17863/CAM.40212
dcterms.dateAccepted2019-05-23en
rioxxterms.versionofrecord10.1186/s12885-019-5746-6en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-06-14en
dc.contributor.orcidWalter, Fiona [0000-0002-7191-6476]
dc.contributor.orcidAbel, Gary A [0000-0003-2231-5161]
dc.contributor.orcidHamilton, William [0000-0003-1611-1373]
dc.contributor.orcidLyratzopoulos, Georgios [0000-0002-2873-7421]
dc.contributor.orcidSpencer, Anne [0000-0002-8163-3103]
dc.contributor.orcidSutton, Stephen [0000-0003-1610-0404]
dc.contributor.orcidVedsted, Peter [0000-0003-2113-5599]
dc.identifier.eissn1471-2407
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (23385)
cam.orpheus.successMon Jun 08 08:21:14 BST 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2022-05-22


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