Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.
Wilson, Liam R
Christian, Bradley T
Handen, Benjamin L
Klunk, William E
Menon, David K
Alzheimer's & dementia (Amsterdam, Netherlands)
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Mak, E., Bickerton, A., Padilla, C., Walpert, M., Annus, T., Wilson, L. R., Hong, Y., et al. (2019). Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.. Alzheimer's & dementia (Amsterdam, Netherlands), 11 654-658. https://doi.org/10.1016/j.dadm.2019.04.006
We report a deep-phenotyping study undertaken over 7 years in a participant with Down syndrome (DS) who was non-demented at baseline but who developed dementia after 5 years. Multi-modal neuroimaging, including three serial scans of [11C]-PiB-PET, four structural MRI, as well as a [18F]-AV1451 scan, were interpreted alongside detailed neuropsychological assessments over the study period. We showed, for the first time in a person with DS, that beta-amyloid accumulation preceded the onset of dementia, which in turn corresponded to the topography of tau within temporo-parietal cortices. These observations highlight the potential for deep-phenotyping imaging to elucidate the substrates of cognitive decline in DS.
Alzheimer's Research UK Health Foundation Medical Research Council NIHR Cambridge Biomedical Research Centre the NIHR Collaborations in Leadership for Applied Health Research and Care (CLAHRC) for the East of England NIHR Cambridge Dementia Biomedical Research Unit Down Syndrome Association
MEDICAL RESEARCH COUNCIL (MR/M009041/1)
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External DOI: https://doi.org/10.1016/j.dadm.2019.04.006
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293092
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