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dc.contributor.authorMak, Elijahen
dc.contributor.authorBickerton, Anastasiaen
dc.contributor.authorPadilla, Concepcionen
dc.contributor.authorWalpert, Madeleineen
dc.contributor.authorAnnus, Tiinaen
dc.contributor.authorWilson, Liam Ren
dc.contributor.authorHong, Youngen
dc.contributor.authorFryer, Timothyen
dc.contributor.authorColes, Jonathanen
dc.contributor.authorAigbirhio, Franklinen
dc.contributor.authorChristian, Bradley Ten
dc.contributor.authorHanden, Benjamin Len
dc.contributor.authorKlunk, William Een
dc.contributor.authorMenon, David Ken
dc.contributor.authorNestor, Peter Jen
dc.contributor.authorZaman, Shahiden
dc.contributor.authorHolland, Anthonyen
dc.date.accessioned2019-05-23T23:30:45Z
dc.date.available2019-05-23T23:30:45Z
dc.date.issued2019-12en
dc.identifier.issn2352-8729
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293092
dc.description.abstractWe report a deep-phenotyping study undertaken over 7 years in a participant with Down syndrome (DS) who was non-demented at baseline but who developed dementia after 5 years. Multi-modal neuroimaging, including three serial scans of [11C]-PiB-PET, four structural MRI, as well as a [18F]-AV1451 scan, were interpreted alongside detailed neuropsychological assessments over the study period. We showed, for the first time in a person with DS, that beta-amyloid accumulation preceded the onset of dementia, which in turn corresponded to the topography of tau within temporo-parietal cortices. These observations highlight the potential for deep-phenotyping imaging to elucidate the substrates of cognitive decline in DS.
dc.description.sponsorshipAlzheimer's Research UK Health Foundation Medical Research Council NIHR Cambridge Biomedical Research Centre the NIHR Collaborations in Leadership for Applied Health Research and Care (CLAHRC) for the East of England NIHR Cambridge Dementia Biomedical Research Unit Down Syndrome Association
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.publisherElsevier
dc.rightsAll rights reserved
dc.rights.uri
dc.titleLongitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.en
dc.typeArticle
prism.endingPage658
prism.publicationDate2019en
prism.publicationNameAlzheimer's & dementia (Amsterdam, Netherlands)en
prism.startingPage654
prism.volume11en
dc.identifier.doi10.17863/CAM.40244
dcterms.dateAccepted2019-04-24en
rioxxterms.versionofrecord10.1016/j.dadm.2019.04.006en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-12en
dc.contributor.orcidMak, Elijah [0000-0002-6437-8024]
dc.contributor.orcidColes, Jonathan [0000-0003-4013-679X]
dc.contributor.orcidAigbirhio, Franklin [0000-0001-9453-5257]
dc.contributor.orcidNestor, Peter J [0000-0002-5860-5921]
dc.contributor.orcidZaman, Shahid [0000-0003-1639-6014]
dc.contributor.orcidHolland, Anthony [0000-0003-4107-130X]
dc.identifier.eissn2352-8729
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1002252)
pubs.funder-project-idMRC (G0900903)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M009041/1)
rioxxterms.freetoread.startdate2022-05-23


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