Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition.
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Authors
Naudin, Sabine
Rebours, Vinciane
Kühn, Tilman
Katzke, Verena
Boeing, Heiner
Olsen, Anja
Lasheras, Cristina
Rodríguez-Barranco, Miguel
Amiano, Pilar
Santiuste, Carmen
Ardanaz, Eva
Khaw, Kay-Thee
Trichopoulou, Antonia
Thriskos, Paschalis
Peppa, Eleni
Masala, Giovanna
Grioni, Sara
Panico, Salvatore
Bueno-de-Mesquita, Bas
Vermeulen, Roel
Sonestedt, Emily
Sund, Malin
Weiderpass, Elisabete
Skeie, Guri
González, Carlos A
Publication Date
2020-01Journal Title
International journal of cancer
ISSN
0020-7136
Publisher
John Wiley & Sons Inc.
Volume
146
Issue
1
Pages
76-84
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M., Mancini, F. R., Rebours, V., et al. (2020). Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition.. International journal of cancer, 146 (1), 76-84. https://doi.org/10.1002/ijc.32415
Abstract
Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95%CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476160 participants were eligible for the present study and included 1283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs non-consumers: HR:0.89, 95%CI:0.72-1.10, P-trend:0.70). Further, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
Keywords
Humans, Nuts, Seeds, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Diet, Proportional Hazards Models, Risk Factors, Prospective Studies, Middle Aged, Europe, Female, Male, Surveys and Questionnaires
Sponsorship
Cancer Research UK (C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (MR/M012190/1 to EPIC-Oxford) (United Kingdom).
Funder references
MRC (MC_UU_12015/1)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
MEDICAL RESEARCH COUNCIL (MR/N003284/1)
MRC (G0401527)
Embargo Lift Date
2021-01-31
Identifiers
External DOI: https://doi.org/10.1002/ijc.32415
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293093
Rights
All rights reserved