Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition.
González, Carlos A
International journal of cancer
John Wiley & Sons Inc.
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Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M., Mancini, F. R., Rebours, V., et al. (2020). Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition.. International journal of cancer, 146 (1), 76-84. https://doi.org/10.1002/ijc.32415
Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95%CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476160 participants were eligible for the present study and included 1283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs non-consumers: HR:0.89, 95%CI:0.72-1.10, P-trend:0.70). Further, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
Humans, Nuts, Seeds, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Diet, Proportional Hazards Models, Risk Factors, Prospective Studies, Middle Aged, Europe, Female, Male, Surveys and Questionnaires
Cancer Research UK (C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (MR/M012190/1 to EPIC-Oxford) (United Kingdom).
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
MEDICAL RESEARCH COUNCIL (MR/N003284/1)
Embargo Lift Date
External DOI: https://doi.org/10.1002/ijc.32415
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293093
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