Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study.
European heart journal
Oxford University Press
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Larsson, S. C., Bäck, M., Rees, J. M., Mason, A., & Burgess, S. (2020). Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study.. European heart journal, 41 (2), 221-226. https://doi.org/10.1093/eurheartj/ehz388
Aims: The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the two-sample Mendelian randomization design to investigate the associations of body mass index (BMI) with 13 CVDs and arterial hypertension. We also assessed the roles of fat mass and fat-free mass on the same outcomes. Methods and results: Single-nucleotide polymorphisms associated with BMI, fat mass and fat-free mass were used as instrumental variables to estimate the associations with the cardiovascular conditions among 367 703 UK Biobank participants. Genetically predicted BMI was significantly positively associated with eight of the 14 outcomes, including and with decreasing magnitude of association: aortic valve stenosis, heart failure, deep vein thrombosis, arterial hypertension, peripheral arterial disease, coronary artery disease, atrial fibrillation, and pulmonary embolism. The odds ratio per 1 kg/m2 increase of genetically predicted BMI ranged from 1.06 (95% CI 1.02–1.11; P=2.610-3) for pulmonary embolism to 1.13 (95% CI 1.05–1.21; P=1.210-3) for aortic valve stenosis. There was evidence of possible positive associations (P<0.05) of genetically predicted fat mass index with nine outcomes. The strongest magnitude of association was with aortic valve stenosis (odds ratio per 1 kg/m2 increase in fat mass 1.46; 95% CI 1.13–1.88; P=3.910-3). In contrast, there was evidence of possible inverse associations of fat-free mass index with atrial fibrillation, ischemic stroke, and abdominal aortic aneurysm. Conclusion: This study provides evidence that higher BMI and particularly fat mass are associated with increased risk of aortic valve stenosis and most other cardiovascular conditions.
Humans, Cardiovascular Diseases, Obesity, Body Mass Index, Incidence, Risk Assessment, Risk Factors, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Biological Specimen Banks, Female, Male, Genome-Wide Association Study, Mendelian Randomization Analysis, United Kingdom
Wellcome Trust (204623/Z/16/Z)
British Heart Foundation (RG/13/13/30194)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (RG/18/13/33946)
Embargo Lift Date
External DOI: https://doi.org/10.1093/eurheartj/ehz388
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293124
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