Heterochronic faecal transplantation boosts gut germinal centres in aged mice
Authors
Stebegg, Marisa
Silva-Cayetano, Alyssa
Innocentin, Silvia
Gilbert, Colin
Journal Title
Nature Communications
ISSN
2041-1723
Publisher
Nature Publishing Group
Type
Article
This Version
VoR
Metadata
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Stebegg, M., Silva-Cayetano, A., Innocentin, S., Jenkins, T., Cantacessi, C., Gilbert, C., & Linterman, M. (2019). Heterochronic faecal transplantation boosts gut germinal centres in aged mice. Nature Communications https://doi.org/10.1038/s41467-019-10430-7
Abstract
Ageing is a complex multifactorial process associated with a plethora of disorders, which contribute significantly to morbidity worldwide. One of the organs significantly affected by age is the gut. Age-dependent changes of the gut-associated microbiome have been linked to increased frailty and systemic inflammation. This change in microbial composition with age occurs in parallel with a decline in function of the gut immune system, however it is not clear if there is a causal link between the two. Here we report that the defective germinal centre reaction in Peyer’s patches of aged mice can be rescued by faecal transfers from younger adults into aged mice and by immunisations with cholera toxin, without affecting germinal centre reactions in peripheral lymph nodes. This demonstrates that the poor germinal centre reaction in aged animals is not irreversible, and that it is possible to improve this response in older individuals by providing appropriate stimuli.
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1038/s41467-019-10430-7
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293232
Rights
Attribution 4.0 International (CC BY)
Licence URL: http://creativecommons.org/licenses/by/4.0/