Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire.

Burzynski, Laura C; Clarke, Murray CH

Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire.

Accepted version

Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/293323

Repository DOI

https://doi.org/10.17863/CAM.40477

Files

Accepted version (108.81 KB)

Type

Article

Authors

Burzynski, Laura C

Clarke, Murray CH

Abstract

Pyroptotic cell death during endotoxemia causes death via unknown mechanisms. In this issue of Immunity, Wu et al. (2019) show that T3SS rod proteins or LPS induces inflammasome activation, macrophage pyroptosis, and accompanying tissue factor release, directly connecting inflammation to coagulation.

Keywords

Blood Coagulation, Humans, Inflammasomes, Inflammation, Macrophages, Pyroptosis

Journal Title

Immunity

Journal ISSN

1074-7613
1097-4180

Volume Title

50

Publisher

Elsevier BV

Publisher DOI

https://doi.org/10.1016/j.immuni.2019.05.015

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International

Sponsorship

British Heart Foundation (None)
British Heart Foundation (RG/16/8/32388)
British Heart Foundation (FS/18/19/33371)
British Heart Foundation (None)
British Heart Foundation (FS/18/19/33371)

The Cambridge NIHR Biomedical Research Centre.

Collections

Cambridge University Research Outputs