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dc.contributor.authorOsimo, Emanuele Feliceen
dc.contributor.authorBaxter, Luke Jamesen
dc.contributor.authorLewis, Glynen
dc.contributor.authorJones, Peteren
dc.contributor.authorKhandaker, Golamen
dc.date.accessioned2019-06-03T23:31:13Z
dc.date.available2019-06-03T23:31:13Z
dc.date.issued2019-09en
dc.identifier.issn0033-2917
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293352
dc.description.abstractBackground Peripheral low-grade inflammation in depression is increasingly seen as a therapeutic target. We aimed to establish the prevalence of low-grade inflammation in depression, using different C-reactive protein (CRP) levels, through a systematic literature review and meta-analysis. Methods We searched the PubMed database from its inception to July 2018, and selected studies that assessed depression using a validated tool/scale, and allowed the calculation of the proportion of patients with low-grade inflammation (CRP >3mg/L) or elevated CRP (>1mg/L). Results After quality assessment, 37 studies comprising 13,541 depressed patients and 155,728 controls were included. Based on meta-analysis of 30 studies, the prevalence of low-grade inflammation (CRP >3mg/L) in depression was 27% (95% CI, 21-34%); this prevalence was not associated with sample source (inpatient, outpatient or population-based), antidepressant treatment, participant age, BMI or ethnicity. Based on meta-analysis of 17 studies of depression and matched healthy controls, the odds ratio for low-grade inflammation in depression was 1.46 (95% CI, 1.22-1.75). The prevalence of elevated CRP (>1mg/L) in depression was 58% (95% CI, 47-69%), and the meta-analytic odds ratio for elevated CRP in depression compared with controls was 1.47 (95% CI, 1.18-1.82). Conclusions About a quarter of patients with depression show evidence of low-grade inflammation, and over half of patients show mildly elevated CRP levels. There are significant differences in the prevalence of low-grade inflammation between patients and matched healthy controls. These findings suggest that inflammation could be relevant for a large number of patients with depression.
dc.description.sponsorshipWellcome Trust (201486/Z/16/Z)
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherCambridge University Press
dc.rightsAll rights reserved
dc.subjectHumansen
dc.subjectInflammationen
dc.subjectC-Reactive Proteinen
dc.subjectAntidepressive Agentsen
dc.subjectPrevalenceen
dc.subjectOdds Ratioen
dc.subjectDepressive Disorderen
dc.titlePrevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels.en
dc.typeArticle
prism.endingPage1970
prism.issueIdentifier12en
prism.publicationDate2019en
prism.publicationNamePsychological medicineen
prism.startingPage1958
prism.volume49en
dc.identifier.doi10.17863/CAM.40506
dcterms.dateAccepted2019-05-30en
rioxxterms.versionofrecord10.1017/s0033291719001454en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-09en
dc.contributor.orcidOsimo, Emanuele Felice [0000-0001-6239-5691]
dc.contributor.orcidLewis, Glyn [0000-0001-5205-8245]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.contributor.orcidKhandaker, Golam [0000-0002-4935-9220]
dc.identifier.eissn1469-8978
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC 2012-2017)
pubs.funder-project-idWellcome Trust (201486/Z/16/Z)
pubs.funder-project-idWellcome Trust (095844/Z/11/Z)
pubs.funder-project-idWellcome Trust (088869/Z/09/Z)
pubs.funder-project-idMRC (MC_PC_17213)
pubs.funder-project-idNational Institute for Health Research (NIHR) (via Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (RP PG-0616-20003)
pubs.funder-project-idMQ: Transforming Mental Health (MQDS17\40)
cam.orpheus.successThu Jan 30 10:44:01 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-03-30


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