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dc.contributor.authorLorenz, Matthias Wen
dc.contributor.authorPrice, Jackie Fen
dc.contributor.authorRobertson, Christineen
dc.contributor.authorBots, Michiel Len
dc.contributor.authorPolak, Joseph Fen
dc.contributor.authorPoppert, Holgeren
dc.contributor.authorKavousi, Maryamen
dc.contributor.authorDörr, Marcusen
dc.contributor.authorStensland, Evaen
dc.contributor.authorDucimetiere, Pierreen
dc.contributor.authorRonkainen, Kimmoen
dc.contributor.authorKiechl, Stefanen
dc.contributor.authorSitzer, Matthiasen
dc.contributor.authorRundek, Tatjanaen
dc.contributor.authorLind, Larsen
dc.contributor.authorLiu, Jingen
dc.contributor.authorBergström, Göranen
dc.contributor.authorGrigore, Lilianaen
dc.contributor.authorBokemark, Lenaen
dc.contributor.authorFriera, Alfonsaen
dc.contributor.authorYanez, Daviden
dc.contributor.authorBickel, Horsten
dc.contributor.authorIkram, M Arfanen
dc.contributor.authorVölzke, Henryen
dc.contributor.authorJohnsen, Stein Haralden
dc.contributor.authorEmpana, Jean Philippeen
dc.contributor.authorTuomainen, Tomi-Pekkaen
dc.contributor.authorWilleit, Peteren
dc.contributor.authorSteinmetz, Helmuthen
dc.contributor.authorDesvarieux, Moiseen
dc.contributor.authorXie, Wuxiangen
dc.contributor.authorSchmidt, Carolineen
dc.contributor.authorNorata, Giuseppe Den
dc.contributor.authorSuarez, Carmenen
dc.contributor.authorSander, Dirken
dc.contributor.authorHofman, Alberten
dc.contributor.authorSchminke, Ulfen
dc.contributor.authorMathiesen, Ellisiven
dc.contributor.authorPlichart, Matthieuen
dc.contributor.authorKauhanen, Jussien
dc.contributor.authorWilleit, Johannen
dc.contributor.authorSacco, Ralph Len
dc.contributor.authorMcLachlan, Stelaen
dc.contributor.authorZhao, Dongen
dc.contributor.authorFagerberg, Björnen
dc.contributor.authorCatapano, Alberico Len
dc.contributor.authorGabriel, Rafaelen
dc.contributor.authorFranco, Oscar Hen
dc.contributor.authorBülbül, Alpaslanen
dc.contributor.authorScheckenbach, Franken
dc.contributor.authorPflug, Anjaen
dc.contributor.authorGao, Luen
dc.contributor.authorThompson, Simonen
dc.date.accessioned2019-06-05T15:01:17Z
dc.date.available2019-06-05T15:01:17Z
dc.date.issued2015-10-01en
dc.identifier.issn1935-5548
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293406
dc.description.abstractOBJECTIVE: Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated examinations with subsequent CVD events is uncertain, and its use as a surrogate end point in clinical trials is controversial. We aimed at determining the relation of CIMT change to CVD events in people with diabetes. RESEARCH DESIGN AND METHODS: In a comprehensive meta-analysis of individual participant data, we collated data from 3,902 adults (age 33-92 years) with type 2 diabetes from 21 population-based cohorts. We calculated the hazard ratio (HR) per standard deviation (SD) difference in mean common carotid artery intima-media thickness (CCA-IMT) or in CCA-IMT progression, both calculated from two examinations on average 3.6 years apart, for each cohort, and combined the estimates with random-effects meta-analysis. RESULTS: Average mean CCA-IMT ranged from 0.72 to 0.97 mm across cohorts in people with diabetes. The HR of CVD events was 1.22 (95% CI 1.12-1.33) per SD difference in mean CCA-IMT, after adjustment for age, sex, and cardiometabolic risk factors. Average mean CCA-IMT progression in people with diabetes ranged between -0.09 and 0.04 mm/year. The HR per SD difference in mean CCA-IMT progression was 0.99 (0.91-1.08). CONCLUSIONS: Despite reproducing the association between CIMT level and vascular risk in subjects with diabetes, we did not find an association between CIMT change and vascular risk. These results do not support the use of CIMT progression as a surrogate end point in clinical trials in people with diabetes.
dc.languageengen
dc.publisherAmerican Diabetes Association
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAtherosclerosisen
dc.subjectCarotid Artery, Commonen
dc.subjectCarotid Intima-Media Thicknessen
dc.subjectCooperative Behavioren
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectDiabetic Angiopathiesen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProportional Hazards Modelsen
dc.subjectRisk Factorsen
dc.titleCarotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration.en
dc.typeArticle
prism.endingPage1929
prism.issueIdentifier10en
prism.publicationDate2015en
prism.publicationNameDiabetes Careen
prism.startingPage1921
prism.volume38en
dc.identifier.doi10.17863/CAM.25232
dcterms.dateAccepted2015-06-20en
rioxxterms.versionofrecord10.2337/dc14-2732en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-10-01en
dc.contributor.orcidGao, Lu [0000-0003-3353-1855]
dc.contributor.orcidThompson, Simon [0000-0002-5274-7814]
dc.identifier.eissn1935-5548
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (RG/08/014/24067)
cam.issuedOnline2015-09-24en


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