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dc.contributor.authorLorenz, Matthias W
dc.contributor.authorPrice, Jackie F
dc.contributor.authorRobertson, Christine
dc.contributor.authorBots, Michiel L
dc.contributor.authorPolak, Joseph F
dc.contributor.authorPoppert, Holger
dc.contributor.authorKavousi, Maryam
dc.contributor.authorDörr, Marcus
dc.contributor.authorStensland, Eva
dc.contributor.authorDucimetiere, Pierre
dc.contributor.authorRonkainen, Kimmo
dc.contributor.authorKiechl, Stefan
dc.contributor.authorSitzer, Matthias
dc.contributor.authorRundek, Tatjana
dc.contributor.authorLind, Lars
dc.contributor.authorLiu, Jing
dc.contributor.authorBergström, Göran
dc.contributor.authorGrigore, Liliana
dc.contributor.authorBokemark, Lena
dc.contributor.authorFriera, Alfonsa
dc.contributor.authorYanez, David
dc.contributor.authorBickel, Horst
dc.contributor.authorIkram, M Arfan
dc.contributor.authorVölzke, Henry
dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorEmpana, Jean Philippe
dc.contributor.authorTuomainen, Tomi-Pekka
dc.contributor.authorWilleit, Peter
dc.contributor.authorSteinmetz, Helmuth
dc.contributor.authorDesvarieux, Moise
dc.contributor.authorXie, Wuxiang
dc.contributor.authorSchmidt, Caroline
dc.contributor.authorNorata, Giuseppe D
dc.contributor.authorSuarez, Carmen
dc.contributor.authorSander, Dirk
dc.contributor.authorHofman, Albert
dc.contributor.authorSchminke, Ulf
dc.contributor.authorMathiesen, Ellisiv
dc.contributor.authorPlichart, Matthieu
dc.contributor.authorKauhanen, Jussi
dc.contributor.authorWilleit, Johann
dc.contributor.authorSacco, Ralph L
dc.contributor.authorMcLachlan, Stela
dc.contributor.authorZhao, Dong
dc.contributor.authorFagerberg, Björn
dc.contributor.authorCatapano, Alberico L
dc.contributor.authorGabriel, Rafael
dc.contributor.authorFranco, Oscar H
dc.contributor.authorBülbül, Alpaslan
dc.contributor.authorScheckenbach, Frank
dc.contributor.authorPflug, Anja
dc.contributor.authorGao, Lu
dc.contributor.authorThompson, Simon G
dc.date.accessioned2019-06-05T15:01:17Z
dc.date.available2019-06-05T15:01:17Z
dc.date.issued2015-10-01
dc.identifier.issn1935-5548
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293406
dc.description.abstractOBJECTIVE: Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated examinations with subsequent CVD events is uncertain, and its use as a surrogate end point in clinical trials is controversial. We aimed at determining the relation of CIMT change to CVD events in people with diabetes. RESEARCH DESIGN AND METHODS: In a comprehensive meta-analysis of individual participant data, we collated data from 3,902 adults (age 33-92 years) with type 2 diabetes from 21 population-based cohorts. We calculated the hazard ratio (HR) per standard deviation (SD) difference in mean common carotid artery intima-media thickness (CCA-IMT) or in CCA-IMT progression, both calculated from two examinations on average 3.6 years apart, for each cohort, and combined the estimates with random-effects meta-analysis. RESULTS: Average mean CCA-IMT ranged from 0.72 to 0.97 mm across cohorts in people with diabetes. The HR of CVD events was 1.22 (95% CI 1.12-1.33) per SD difference in mean CCA-IMT, after adjustment for age, sex, and cardiometabolic risk factors. Average mean CCA-IMT progression in people with diabetes ranged between -0.09 and 0.04 mm/year. The HR per SD difference in mean CCA-IMT progression was 0.99 (0.91-1.08). CONCLUSIONS: Despite reproducing the association between CIMT level and vascular risk in subjects with diabetes, we did not find an association between CIMT change and vascular risk. These results do not support the use of CIMT progression as a surrogate end point in clinical trials in people with diabetes.
dc.languageeng
dc.publisherAmerican Diabetes Association
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAtherosclerosis
dc.subjectCarotid Artery, Common
dc.subjectCarotid Intima-Media Thickness
dc.subjectCooperative Behavior
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiabetic Angiopathies
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProportional Hazards Models
dc.subjectRisk Factors
dc.titleCarotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration.
dc.typeArticle
prism.endingPage1929
prism.issueIdentifier10
prism.publicationDate2015
prism.publicationNameDiabetes Care
prism.startingPage1921
prism.volume38
dc.identifier.doi10.17863/CAM.25232
dcterms.dateAccepted2015-06-20
rioxxterms.versionofrecord10.2337/dc14-2732
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-10-01
dc.contributor.orcidGao, Lu [0000-0003-3353-1855]
dc.contributor.orcidThompson, Simon [0000-0002-5274-7814]
dc.identifier.eissn1935-5548
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (None)
cam.issuedOnline2015-09-24


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