A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.

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Authors
  Vasiliauskaitė, Lina
  Vitsios, Dimitrios
Berrens, Rebecca V
Carrieri, Claudia
Reik, Wolf
Enright, Anton J
O'Carroll, Dónal
Publication Date
2017-07
Journal Title
Nat Struct Mol Biol
ISSN
1545-9993
Publisher
Springer Science and Business Media LLC
Volume
24
Issue
7
Pages
604-606
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
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Citation
Vasiliauskaitė, L., Vitsios, D., Berrens, R. V., Carrieri, C., Reik, W., Enright, A. J., & O'Carroll, D. (2017). A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.. Nat Struct Mol Biol, 24 (7), 604-606. https://doi.org/10.1038/nsmb.3413
Abstract
In mice, the pathway involving PIWI and PIWI-interacting RNA (PIWI-piRNA) is essential to re-establish transposon silencing during male-germline reprogramming. The cytoplasmic PIWI protein MILI mediates piRNA-guided transposon RNA cleavage as well as piRNA amplification. MIWI2's binding to piRNA and its nuclear localization are proposed to be dependent upon MILI function. Here, we demonstrate the existence of a piRNA biogenesis pathway that sustains partial MIWI2 function and reprogramming activity in the absence of MILI.
Keywords
Animals, Argonaute Proteins, Gene Expression Regulation, Mice, Mice, Knockout, RNA, Small Interfering
Identifiers
External DOI: https://doi.org/10.1038/nsmb.3413
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293701
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