We examine the published empirical literature in healthcare operations management over the last 20 years. We note several unique characteristics of the research in healthcare operations, including a focus on operational and organizational variables, an interest in the underlying mechanisms that explain operational causal pathways, and an interest in economic and managerial implications. We organize the prior findings under five distinct themes: importance of operational variables, importance of volume, routing patients through healthcare systems, to err is human, and managing the improvement process. We also identify several key areas of future research, including personalized medicine, value based healthcare, and connected health. We conclude with a call to action for greater engagement with the medical community in areas where tools and insights of operations management can bring about improvements in healthcare delivery.