Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization.
Institute of Physics Publishing
MetadataShow full item record
Rickman, J., Nédélec, F., & Surrey, T. (2019). Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization.. Physical Biology, 16 (046004)https://doi.org/10.1088/1478-3975/ab0fb1
Active networks composed of filaments and motor proteins can self-organize into a variety of architectures. Computer simulations in two or three spatial dimensions and including or omitting steric interactions between filaments can be used to model active networks. Here we examine how these modelling choices affect the state space of network self-organization. We compare the networks generated by different models of a system of dynamic microtubules and microtubule-crosslinking motors. We find that a thin 3D model that includes steric interactions between filaments is the most versatile, capturing a variety of network states observed in recent experiments. In contrast, 2D models either with or without steric interactions which prohibit microtubule crossings can produce some, but not all, observed network states. Our results provide guidelines for the most appropriate choice of model for the study of different network types and elucidate mechanisms of active network organization.
This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001163), the UK Medical Research Council (FC001163), and the Wellcome Trust (FC001163). F N was supported by the Centre for Modelling in the Biosciences (www.bioms.de) and EMBL. T S acknowledges support from the European Research Council (Advanced Grant, project 323042). We thank EMBL for support, in particular for its high-performance computing services.
External DOI: https://doi.org/10.1088/1478-3975/ab0fb1
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293827
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/