Collaboration can be pivotal in making change happen. So how can new collaborative models be forged in areas where such relationships are not well established, but where change is required? In UK medicines manufacturing, there is an opportunity and a pressing need for progressive change. But there are also plenty of challenges and obstacles, particularly in a highly competitive and tightly regulated sector. A bold step forward has been taken through a collaborative £23m four-year project, ReMediES, involving 22 industry partners and 2 leading UK Universities. Dr Jag Srai and Professor Clive Badman, co-Directors of Project ReMediES discuss how the project has forged a model for change through collaboration.