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dc.contributor.authorHill, Danika Len
dc.contributor.authorPierson, Wimen
dc.contributor.authorBolland, Daniel Johnen
dc.contributor.authorMkindi, Catherineen
dc.contributor.authorCarr, Edwarden
dc.contributor.authorWang, Jiongen
dc.contributor.authorHouard, Sophieen
dc.contributor.authorWingett, Steven Wen
dc.contributor.authorAudran, Regineen
dc.contributor.authorWallin, Elizabeth Fen
dc.contributor.authorJongo, Said Aen
dc.contributor.authorKamaka, Kassimen
dc.contributor.authorZand, Martinen
dc.contributor.authorSpertini, Francoisen
dc.contributor.authorDaubenberger, Claudiaen
dc.contributor.authorCorcoran, Anne Elizabethen
dc.contributor.authorLinterman, Michelleen
dc.date.accessioned2019-06-21T10:36:42Z
dc.date.available2019-06-21T10:36:42Z
dc.date.issued2019-06-03en
dc.identifier.issn0022-1007
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293842
dc.description.abstract<jats:p>The generation of protective humoral immunity after vaccination relies on the productive interaction between antigen-specific B cells and T follicular helper (Tfh) cells. Despite the central role of Tfh cells in vaccine responses, there is currently no validated way to enhance their differentiation in humans. From paired human lymph node and blood samples, we identify a population of circulating Tfh cells that are transcriptionally and clonally similar to germinal center Tfh cells. In a clinical trial of vaccine formulations, circulating Tfh cells were expanded in Tanzanian volunteers when an experimental malaria vaccine was adjuvanted in GLA-SE but not when formulated in Alum. The GLA-SE–formulated peptide was associated with an increase in the extrafollicular antibody response, long-lived antibody production, and the emergence of public TCRβ clonotypes in circulating Tfh cells. We demonstrate that altering vaccine adjuvants is a rational approach for enhancing Tfh cells in humans, thereby supporting the long-lived humoral immunity that is required for effective vaccines.</jats:p>
dc.languageenen
dc.publisherRockefeller University Press
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleThe adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypesen
dc.typeArticle
prism.endingPagejem.20190301
prism.issueIdentifier6en
prism.publicationDate2019en
prism.publicationNameThe Journal of Experimental Medicineen
prism.startingPagejem.20190301
prism.volume216en
dc.identifier.doi10.17863/CAM.40954
dcterms.dateAccepted2019-05-14en
rioxxterms.versionofrecord10.1084/jem.20190301en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2019-06-03en
dc.contributor.orcidHill, Danika L [0000-0001-6284-7061]
dc.contributor.orcidCarr, Edward [0000-0001-9343-4593]
dc.contributor.orcidCorcoran, Anne Elizabeth [0000-0002-9577-5313]
dc.contributor.orcidLinterman, Michelle [0000-0001-6047-1996]
dc.identifier.eissn1540-9538
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-06-07en
dc.identifier.urlhttps://elements.admin.cam.ac.uk/objectedit.html?cid=1&ot=5&oid=1101279&rid=3074962en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International