Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.

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Authors
  Koohy, Hashem
Bolland, Daniel John
  Matheson, Louise Sarah
  Schoenfelder, Stefan
Stellato, Claudia
  Dimond, Andrew
  Várnai, Csilla
Publication Date
2018-09-05
Journal Title
Genome biology
ISSN
1474-7596
Volume
19
Issue
1
Pages
126
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
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Citation
Koohy, H., Bolland, D. J., Matheson, L. S., Schoenfelder, S., Stellato, C., Dimond, A., Várnai, C., et al. (2018). Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.. Genome biology, 19 (1), 126. https://doi.org/10.1186/s13059-018-1489-y
Keywords
B-Lymphocytes, Chromatin, Stem Cells, Animals, Mice, Inbred C57BL, Somatomedins, Signal Transduction, Down-Regulation, Epigenesis, Genetic, Aging, Genome, Male, Transcriptome
Sponsorship
Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0405)
Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0404)
Identifiers
External DOI: https://doi.org/10.1186/s13059-018-1489-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293936

Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International