Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Clark, Stephen James https://orcid.org/0000-0002-6183-491X
Lee, Heather J
Smallwood, Sébastien A
Kelsey, Gavin https://orcid.org/0000-0002-9762-5634
Reik, Wolf https://orcid.org/0000-0003-0216-9881
Abstract
Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies will be realized through parallel profiling of genomic, transcriptional, and epigenetic information.
Description
Keywords
Animals, DNA Methylation, Epigenomics, Gene Expression Regulation, Humans, Single-Cell Analysis
Journal Title
Genome Biol
Conference Name
Journal ISSN
1474-7596
1474-760X
1474-760X
Volume Title
17
Publisher
Springer Science and Business Media LLC