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dc.contributor.authorCantacessi, Cinziaen
dc.date.accessioned2019-06-24T23:32:13Z
dc.date.available2019-06-24T23:32:13Z
dc.identifier.issn1469-8161
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293973
dc.description.abstractThe multifaceted interactions occurring between gastrointestinal (GI) parasitic helminths and the host gut microbiota are emerging as a key area of study within the broader research domain of host-pathogen relationships. Over the past few years, a wealth of investigations has demonstrated that GI helminths interact with the host gut flora, and that such interactions result in modifications of the host immune and metabolic statuses. Nevertheless, whilst selected changes in gut microbial composition are consistently observed in response to GI helminth infections across several host-parasite systems, research in this area to date is largely characterised by inconsistent findings. These discrepancies are particularly evident when data from studies of GI helminth-microbiota interactions conducted in humans from parasite-endemic regions are compared. In this review, we provide an overview of the main sources of variance that affect investigations on human-helminth-gut microbiota interactions and propose a series of methodological approaches that, whilst accounting for the inevitable constraints of human fieldwork, are aimed at minimising confounding factors and draw biologically meaningful interpretations from highly variable datasets.
dc.publisherCambridge University Press
dc.rightsAll rights reserved
dc.rights.uri
dc.titleHelminths and microbes within the vertebrate gut – not all studies are created equalen
dc.typeArticle
prism.endingPage1378
prism.issueIdentifier11en
prism.publicationNameParasitologyen
prism.startingPage1371
prism.volume146en
dc.identifier.doi10.17863/CAM.41081
dcterms.dateAccepted2019-06-23en
rioxxterms.versionofrecord10.1017/S003118201900088Xen
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-06-23en
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn1469-8161
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-07-31en
cam.orpheus.successThu Jan 30 10:44:21 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-01-31


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