The ALBI grade provides objective hepatic reserve estimation across each BCLC stage of hepatocellular carcinoma.
Pinato, David J
Jang, Jeong Won
Kim, Young Woon
Burlone, Michela E
Journal of hepatology
MetadataShow full item record
Pinato, D. J., Sharma, R., Allara, E., Yen, C., Arizumi, T., Kubota, K., Bettinger, D., et al. (2017). The ALBI grade provides objective hepatic reserve estimation across each BCLC stage of hepatocellular carcinoma.. Journal of hepatology, 66 (2), 338-346. https://doi.org/10.1016/j.jhep.2016.09.008
BACKGROUND & AIMS: Overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma (HCC) due to the mutual influence of cirrhosis and active malignancy in dictating patient's mortality. The ALBI grade is a recently described index of liver dysfunction in hepatocellular carcinoma, based solely on albumin and bilirubin levels. Whilst accurate, this score lacks cross-validation, especially in intermediate stage HCC, where OS is highly heterogeneous. METHODS: We evaluated the prognostic accuracy of the ALBI grade in estimating OS in a large, multi-centre study of 2426 patients, including a large proportion of intermediate stage patients treated with chemoembolization (n=1461) accrued from Europe, the United States and Asia. RESULTS: Analysis of survival by primary treatment modality confirmed the ALBI grade as a significant predictor of patient OS after surgical resection (p<0.001), transarterial chemoembolization (p<0.001) and sorafenib (p<0.001). Stratification by Barcelona Clinic Liver Cancer stage confirmed the independent prognostic value of the ALBI across the diverse stages of the disease, geographical regions of origin and time of recruitment to the study (p<0.001). CONCLUSIONS: In this large, multi-centre retrospective study, the ALBI grade satisfied the criteria for accuracy and reproducibility following statistical validation in Eastern and Western HCC patients, including those treated with chemoembolization. Consideration should be given to the ALBI grade as a stratifying biomarker of liver reserve in routine clinical practice. LAY SUMMARY: Liver failure is a key determinant influencing the natural history of hepatocellular carcinoma (HCC). In this large multi-centre study we externally validate a novel biomarker of liver functional reserve, the ALBI grade, across all the stages of HCC.
Liver, Humans, Carcinoma, Hepatocellular, Liver Neoplasms, Liver Failure, Bilirubin, Serum Albumin, Neoplasm Staging, Prognosis, Chemoembolization, Therapeutic, Survival Analysis, Reproducibility of Results, Adult, Aged, Middle Aged, Europe, Female, Male, Organ Dysfunction Scores, Biomarkers, Tumor
No specific funding was obtained to support the conduction of this study.
External DOI: https://doi.org/10.1016/j.jhep.2016.09.008
This record's URL: https://www.repository.cam.ac.uk/handle/1810/294090
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/