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dc.contributor.authorLancaster, Madeline Aen
dc.contributor.authorHuch Ortega, Meritxellen
dc.date.accessioned2019-06-27T23:31:04Z
dc.date.available2019-06-27T23:31:04Z
dc.date.issued2019-07-29en
dc.identifier.issn1754-8403
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/294114
dc.description.abstractAbstract: The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ development to homeostasis and disease. Because organoids develop according to intrinsic developmental programs, the resultant tissue morphology recapitulates organ architecture with remarkable fidelity. Furthermore, the fact that these tissues can be derived from human progenitors allows for the study of uniquely human processes and disorders. This review and accompanying poster highlights the currently available methods, particularly those approaches modelling human biology, and provides an overview of their capabilities and limitations. We will also speculate on possible future technological advances that have the potential for great strides in both disease modelling and future regenerative strategies.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherCompany of Biologists
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectOrganoidsen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectModels, Biologicalen
dc.titleDisease modelling in human organoids.en
dc.typeArticle
prism.issueIdentifier7en
prism.publicationDate2019en
prism.publicationNameDisease models & mechanismsen
prism.volume12en
dc.identifier.doi10.17863/CAM.41215
dcterms.dateAccepted2019-06-18en
rioxxterms.versionofrecord10.1242/dmm.039347en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-07-29en
dc.contributor.orcidLancaster, Madeline A [0000-0003-2324-8853]
dc.contributor.orcidHuch, Meritxell [0000-0002-1545-5265]
dc.identifier.eissn1754-8411
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (104151/Z/14/Z)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Research Infrastructures (RI) (668350)
pubs.funder-project-idNC3Rs (NC/R001162/1)
cam.orpheus.successMon Jun 08 08:19:56 BST 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2022-06-27


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