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dc.contributor.authorMauricio, Rui
dc.contributor.authorBenn, Caroline
dc.contributor.authorDavis, John
dc.contributor.authorDawson, Gerry
dc.contributor.authorDawson, Lee A
dc.contributor.authorEvans, Alison
dc.contributor.authorFox, Nick
dc.contributor.authorGallacher, John
dc.contributor.authorHutton, Mike
dc.contributor.authorIsaac, John
dc.contributor.authorJones, Declan NC
dc.contributor.authorJones, Lesley
dc.contributor.authorLalli, Giovanna
dc.contributor.authorLibri, Vincenzo
dc.contributor.authorLovestone, Simon
dc.contributor.authorMoody, Catherine
dc.contributor.authorNoble, Wendy
dc.contributor.authorPerry, Hugh
dc.contributor.authorPickett, James
dc.contributor.authorReynolds, David
dc.contributor.authorRitchie, Craig
dc.contributor.authorRohrer, Jonathan D
dc.contributor.authorRoutledge, Carol
dc.contributor.authorRowe, James
dc.contributor.authorSnyder, Heather
dc.contributor.authorSpires-Jones, Tara
dc.contributor.authorSwartz, Jina
dc.contributor.authorTruyen, Luc
dc.contributor.authorWhiting, Paul
dc.contributor.authorTherapeutics for Dementia Consortium
dc.date.accessioned2019-07-12T23:30:20Z
dc.date.available2019-07-12T23:30:20Z
dc.date.issued2019
dc.identifier.issn2352-8737
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/294583
dc.description.abstractSince the G8 dementia summit in 2013, a number of initiatives have been established with the aim of facilitating the discovery of a disease-modifying treatment for dementia by 2025. This report is a summary of the findings and recommendations of a meeting titled "Tackling gaps in developing life-changing treatments for dementia", hosted by Alzheimer's Research UK in May 2018. The aim of the meeting was to identify, review, and highlight the areas in dementia research that are not currently being addressed by existing initiatives. It reflects the views of leading experts in the field of neurodegeneration research challenged with developing a strategic action plan to address these gaps and make recommendations on how to achieve the G8 dementia summit goals. The plan calls for significant advances in (1) translating newly identified genetic risk factors into a better understanding of the impacted biological processes; (2) enhanced understanding of selective neuronal resilience to inform novel drug targets; (3) facilitating robust and reproducible drug-target validation; (4) appropriate and evidence-based selection of appropriate subjects for proof-of-concept clinical trials; (5) improving approaches to assess drug-target engagement in humans; and (6) innovative approaches in conducting clinical trials if we are able to detect disease 10-15 years earlier than we currently do today.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherWiley
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectTherapeutics for Dementia Consortium
dc.titleTackling gaps in developing life-changing treatments for dementia.
dc.typeArticle
prism.endingPage253
prism.publicationDate2019
prism.publicationNameAlzheimers Dement (N Y)
prism.startingPage241
prism.volume5
dc.identifier.doi10.17863/CAM.41691
rioxxterms.versionofrecord10.1016/j.trci.2019.05.001
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-01
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn2352-8737
rioxxterms.typeJournal Article/Review
cam.issuedOnline2019-06-25


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International