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Nonlinear and nonlocal elasticity in coarse-grained differential-tension models of epithelia.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Haas, Pierre A 
Goldstein, Raymond E 

Abstract

The shapes of epithelial tissues result from a complex interplay of contractile forces in the cytoskeleta of the cells in the tissue and adhesion forces between them. A host of discrete, cell-based models describe these forces by assigning different surface tensions to the apical, basal, and lateral sides of the cells. These differential-tension models have been used to describe the deformations of epithelia in different living systems, but the underlying continuum mechanics at the scale of the epithelium are still unclear. Here, we derive a continuum theory for a simple differential-tension model of a two-dimensional epithelial monolayer and study the buckling of this epithelium under imposed compression. The analysis reveals how the cell-level properties encoded in the differential-tension model lead to linear and nonlinear elastic as well as nonlocal, nonelastic behavior at the continuum level.

Description

Keywords

Biomechanical Phenomena, Cell Differentiation, Elasticity, Epithelial Cells, Models, Biological, Nonlinear Dynamics, Stress, Mechanical

Journal Title

Phys Rev E

Conference Name

Journal ISSN

2470-0045
2470-0053

Volume Title

99

Publisher

American Physical Society (APS)
Sponsorship
Engineering and Physical Sciences Research Council (EP/M017982/1)
Wellcome Trust (207510/Z/17/Z)