Pro-Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE-PD.
Yarnall, Alison J
Duncan, Gordon W
Khoo, Tien K
Burn, David J
ICICLE-PD study group,
Movement disorders : official journal of the Movement Disorder Society
John Wiley & Sons Inc.
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Stuart, S., Lawson, R. A., Yarnall, A. J., Nell, J., Alcock, L., Duncan, G. W., Khoo, T. K., et al. (2019). Pro-Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE-PD.. Movement disorders : official journal of the Movement Disorder Society, 34 (11), 1690-1698. https://doi.org/10.1002/mds.27813
Objectives Cumulative dementia incidence in Parkinson’s disease (PD) is significant, with major personal and socioeconomic impacts upon individuals with PD and their carers. Early identification of dementia risk is vital to ensure optimal intervention. Saccadic deficits often distinguish neurodegenerative disorders and cognitive impairment, but their ability to predict cognitive decline in PD has yet to be determined. Study aims: 1) evaluate baseline (6.4±6.1months since PD diagnosis) differences in pro-saccadic metrics between those with early PD and healthy age-matched adults; and 2) assess the ability of baseline pro-saccades to predict subsequent cognitive decline over 4.5 years. Methods One hundred and forty-one PD and 90 age-matched participants recruited at diagnosis underwent saccadometric assessment of pro-saccades at baseline and had cognition assessed at baseline, 18, 36 and 54-months. Pro-saccadic characteristics included latency, duration, amplitude, peak and average velocity. Cognitive assessment included executive function, attention, fluctuating attention and memory. Linear mixed-effects models examined pro-saccadic metrics as predictors of cognitive decline over 54-months. Results Pro-saccades were significantly impaired at baseline in PD compared with controls. Pro-saccadic characteristics of latency, duration, peak and average velocity predicted decline in global cognition, executive function, attention and memory over 54-months in PD. Additionally, only reduction in global cognition and attention were predicted by pro-saccadic metrics in age-matched adults, indicating that PD findings were not purely age-related. Conclusion Saccadic characteristics are impaired in early-PD and are predictive of cognitive decline in several domains. Assessment of saccades may provide a useful non-invasive biomarker for long-term PD cognitive decline in early disease.
ICICLE-PD study group, Humans, Parkinson Disease, Dementia, Cognition, Memory, Attention, Adult, Aged, Middle Aged, Female, Male, Executive Function, Cognitive Dysfunction
This work was funded by grants from Parkinson’s UK (J-0802, G-1301, G-1507) and Lockhart Parkinson’s Disease Research Fund. The research was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Unit based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University and a NIHR Biomedical Research Centre award to the University of Cambridge/Addenbrooke’s Hospital.
WELLCOME TRUST (103838/Z/14/Z)
Medical Research Council (MC_U105597119)
External DOI: https://doi.org/10.1002/mds.27813
This record's URL: https://www.repository.cam.ac.uk/handle/1810/294866
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