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dc.contributor.authorWarrier, Varunen
dc.contributor.authorToro, Robertoen
dc.contributor.authorWon, Hyejungen
dc.contributor.authorLeblond, Claireen
dc.contributor.authorCliquet, Freddyen
dc.contributor.authorDelorme, Richarden
dc.contributor.authorDe Witte, Warden
dc.contributor.authorBralten, Janitaen
dc.contributor.authorChakrabarti, Bhismadeven
dc.contributor.authorBorglum, Andersen
dc.contributor.authorGrove, Jakoben
dc.contributor.authorPoelmans, Geerten
dc.contributor.authorResearch Team, 23andMeen
dc.contributor.authorHinds, Daviden
dc.contributor.authorBourgeron, Thomasen
dc.contributor.authorBaron-Cohen, Simonen
dc.date.accessioned2019-07-24T23:30:55Z
dc.date.available2019-07-24T23:30:55Z
dc.identifier.issn2399-3642
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/294875
dc.description.abstractThe core diagnostic criteria for autism comprise two symptom domains – social and communication difficulties, and unusually repetitive and restricted behaviour, interests and activities. There is some evidence to suggest that these two domains are dissociable, yet, this hypothesis has not been tested using molecular genetics. We test this using a GWAS of a non-social autistic trait, systemizing (N = 51,564), defined as the drive to analyse and build systems. We demonstrate that systemizing is heritable and genetically correlated with autism. In contrast, we do not identify significant genetic correlations between social autistic traits and systemizing. Supporting this, polygenic scores for systemizing are significantly positively associated with restricted and repetitive behaviour but not with social difficulties in autistic individuals. These findings strongly suggest that the two core domains of autism are genetically dissociable, and point at how to fractionate the genetics of autism.
dc.rightsAttribution 4.0 International (CC BY)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleSocial and non-social autism symptom and trait domains are genetically dissociableen
dc.typeArticle
prism.publicationNameCommunications Biologyen
dc.identifier.doi10.17863/CAM.41964
dcterms.dateAccepted2019-07-19en
rioxxterms.versionofrecord10.1038/s42003-019-0558-4en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-07-19en
dc.contributor.orcidBaron-Cohen, Simon [0000-0001-9217-2544]
dc.identifier.eissn2399-3642
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-09-03en
cam.orpheus.successMon Jun 08 08:21:12 BST 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International (CC BY)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY)