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dc.contributor.authorBarrett, Daviden
dc.contributor.authorLinley, Matthew Den
dc.contributor.authorBest, Serenaen
dc.contributor.authorCameron, Ruthen
dc.date.accessioned2019-07-25T23:30:23Z
dc.date.available2019-07-25T23:30:23Z
dc.date.issued2019-08-22en
dc.identifier.issn1758-5082
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/294916
dc.description.abstractThis work reports an important new development in the production of collagen membranes, based on pulsed electrophoretic deposition (P-EPD), suitable for a wide range of biomedical applications. Collagen membranes are of great interest as a biomaterial and in a range of other industries, though current production techniques suffer from limitations with scaling up, homogeneity, and complex shapes. P-EPD can be used to rapidly create detachable, large-area, homogeneous products with controlled thickness in a wide variety of shapes. We provide a new understanding of the influence of a range of parameters (pulse width, voltage, duty cycle, solvent additions) and their effects on membrane structure. Characterisation by AFM, SEM, and cryoSEM revealed the ability to produce dense, structurally defect-free membranes, and significantly, we show and discuss the ability to produce thicker membranes by sequential deposition without seeing a corresponding increase in cell electrical resistance. We anticipate this novel, rapid, and controllable method for the production of collagen membranes to be of interest for a wide range of fields.
dc.description.sponsorshipThe authors wish to acknowledge the support of theEngineering and Physical Sciences Research Council(EPSRC)grants EP/K503009/1, EP/J500380/1, EP/L504920/1, EP/M506485/1, and EP/M508007/1,Geistlich Pharma AG, and the European ResearchCouncil(ERC)Advanced Grant 320598 3D-E
dc.format.mediumElectronicen
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectAnimalsen
dc.subjectCattleen
dc.subjectCollagenen
dc.subjectMembranes, Artificialen
dc.subjectHydrogelsen
dc.subjectSolventsen
dc.subjectImaging, Three-Dimensionalen
dc.subjectElectrophoresisen
dc.subjectStatic Electricityen
dc.titleFabrication of free standing collagen membranes by pulsed-electrophoretic deposition.en
dc.typeArticle
prism.issueIdentifier4en
prism.publicationDate2019en
prism.publicationNameBiofabricationen
prism.startingPage045017
prism.volume11en
dc.identifier.doi10.17863/CAM.42003
dcterms.dateAccepted2019-07-17en
rioxxterms.versionofrecord10.1088/1758-5090/ab331den
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-08-22en
dc.contributor.orcidBarrett, David [0000-0002-1692-2574]
dc.contributor.orcidBest, Serena [0000-0001-7866-8607]
dc.contributor.orcidCameron, Ruth [0000-0003-1573-4923]
dc.identifier.eissn1758-5090
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (320598)
pubs.funder-project-idEPSRC (1365562)
pubs.funder-project-idEPSRC (EP/K503009/1)
pubs.funder-project-idEPSRC (EP/L504920/1)
pubs.funder-project-idEPSRC (EP/M506485/1)
pubs.funder-project-idEPSRC (EP/M508007/1)
cam.orpheus.successThu Jan 30 10:42:57 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-08-22


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