pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Sutherland, Colin J
Lansdell, Paul
Sanders, Mandy
Muwanguzi, Julian
van Schalkwyk, Donelly A
Abstract
We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.
Description
Keywords
antimalarial agents, drug resistance mechanisms, imported malaria, parasite genotyping, treatment failure, Africa, Aged, Antimalarials, Artemether, Lumefantrine Drug Combination, Artemisinins, Drug Combinations, Drug Resistance, Ethanolamines, Female, Fluorenes, Gene Expression, Genetic Loci, Humans, Malaria, Falciparum, Male, Parasitemia, Plasmodium falciparum, Protozoan Proteins, Recurrence, Travel, Treatment Failure, United Kingdom, Young Adult
Journal Title
Antimicrob Agents Chemother
Conference Name
Journal ISSN
0066-4804
1098-6596
1098-6596
Volume Title
61
Publisher
American Society for Microbiology
Publisher DOI
Sponsorship
Medical Research Council (G0701652)