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pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Sutherland, Colin J 
Lansdell, Paul 
Sanders, Mandy 
Muwanguzi, Julian 
van Schalkwyk, Donelly A 

Abstract

We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.

Description

Keywords

antimalarial agents, drug resistance mechanisms, imported malaria, parasite genotyping, treatment failure, Africa, Aged, Antimalarials, Artemether, Lumefantrine Drug Combination, Artemisinins, Drug Combinations, Drug Resistance, Ethanolamines, Female, Fluorenes, Gene Expression, Genetic Loci, Humans, Malaria, Falciparum, Male, Parasitemia, Plasmodium falciparum, Protozoan Proteins, Recurrence, Travel, Treatment Failure, United Kingdom, Young Adult

Journal Title

Antimicrob Agents Chemother

Conference Name

Journal ISSN

0066-4804
1098-6596

Volume Title

61

Publisher

American Society for Microbiology
Sponsorship
Medical Research Council (G0701652)