Mitochondrial DNA: the overlooked oncogenome?
Published version
Peer-reviewed
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Repository DOI
Change log
Authors
Gammage, Payam A
Frezza, Christian https://orcid.org/0000-0002-3293-7397
Abstract
Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically neglected source is that of the mitochondrial genome. Recent large-scale sequencing efforts and clinical studies have highlighted the prevalence of mutations in mitochondrial DNA (mtDNA) in human tumours and their potential roles in cancer progression. In this review we discuss the biology of the mitochondrial genome, sources of mtDNA mutations, and experimental evidence of a role for mtDNA mutations in cancer. We also propose a 'metabolic licensing' model for mtDNA mutation-derived dysfunction in cancer initiation and progression.
Description
Keywords
Cancer, Metabolism, Mitochondria, mtDNA
Journal Title
BMC Biology
Conference Name
Journal ISSN
1741-7007
1741-7007
1741-7007
Volume Title
17
Publisher
BioMed Central
Publisher DOI
Sponsorship
Medical Research Council (MC_UU_12022/6)
Medical Research Council (MC_UU_00015/4)
Medical Research Council (MC_UU_00015/7)
Medical Research Council (MC_UU_00015/4)
Medical Research Council (MC_UU_00015/7)
This work was supported by the Medical Research Council (MC_UU_00015/4 and MC_UU_12022/6).