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dc.contributor.authorDavis, Julie Een
dc.contributor.authorWard, Robert Jen
dc.contributor.authorMacKay, Jamesen
dc.contributor.authorLu, Bingen
dc.contributor.authorPrice, Lori Lynen
dc.contributor.authorMcAlindon, Timothy Een
dc.contributor.authorEaton, Charles Ben
dc.contributor.authorBarbe, Mary Fen
dc.contributor.authorLo, Grace Hen
dc.contributor.authorHarkey, Matthew Sen
dc.contributor.authorDriban, Jeffrey Ben
dc.date.accessioned2019-08-12T10:56:18Z
dc.date.available2019-08-12T10:56:18Z
dc.date.issued2018-10-20en
dc.identifier.issn1462-0324
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/295643
dc.description.abstractObjectives: To determine whether greater effusion-synovitis volume and infrapatellar fat pad (IFP) signal intensity alteration differentiate incident accelerated knee OA (KOA) from a gradual onset of KOA or no KOA. Methods: We classified three sex-matched groups of participants in the Osteoarthritis Initiative who had a knee with no radiographic KOA at baseline (recruited 2004-06; Kellgren-Lawrence <2; n = 125/group): accelerated KOA: ⩾1 knee progressed to Kellgren-Lawrence grade ⩾3 within 48 months; common KOA: ⩾1 knee increased in radiographic scoring within 48 months; and no KOA: both knees had the same Kellgren-Lawrence grade at baseline and 48 months. The observation period included up to 2 years before and after when the group criteria were met. Two musculoskeletal radiologists reported presence of IFP signal intensity alteration and independent readers used a semi-automated method to segment effusion-synovitis volume. We used generalized linear mixed models with group and time as independent variables, as well as testing a group-by-time interaction. Results: Starting at 2 years before disease onset, adults who developed accelerated KOA had greater effusion-synovitis volume than their peers (accelerated KOA: 11.94 ± 0.90 cm3, KOA: 8.29 ± 1.19 cm3, no KOA: 8.14 ± 0.90 cm3) and have greater odds of having IFP signal intensity alteration than those with no KOA (odds ratio = 2.07, 95% CI = 1.14-3.78). Starting at 1 year prior to disease onset, those with accelerated KOA have greater than twice the odds of having IFP signal intensity alteration than those with common KOA. Conclusion: People with IFP signal intensity alteration and/or greater effusion-synovitis volume in the absence of radiographic KOA may be at high risk for accelerated KOA, which may be characterized by local inflammation.
dc.languageengen
dc.language.isoenen
dc.publisherOxford University Press
dc.subjectosteoarthritisen
dc.subjectsynoviumen
dc.subjectkneeen
dc.subjectepidemiologyen
dc.subjectMRIen
dc.titleEffusion-synovitis and infrapatellar fat pad signal intensity alteration differentiate accelerated knee osteoarthritis.en
dc.typeArticle
prism.endingPage426
prism.issueIdentifier3en
prism.publicationDate2018en
prism.publicationNameRheumatology (Oxford)en
prism.startingPage418
prism.volume58en
dc.identifier.doi10.17863/CAM.42692
dcterms.dateAccepted2018-09-04en
rioxxterms.versionofrecord10.1093/rheumatology/key305en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-10-20en
dc.contributor.orcidMacKay, James [0000-0001-7558-3800]
dc.identifier.eissn1462-0332
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2019-10-20


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